Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
75 participants
INTERVENTIONAL
2016-03-28
2019-04-27
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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Placebo
Isotonic saline
Placebo
Ketamine
Ketamine Injectable Solution
Active comparator
Interventions
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Isotonic saline
Placebo
Ketamine Injectable Solution
Active comparator
Eligibility Criteria
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Inclusion Criteria
* ASA I - IV
* Undergoing primary unilateral elective total knee arthroplasty with spinal anesthesia
Exclusion Criteria
* Contraindication or allergy to opioid pain medication or ketamine\*
* Daily opioid use for pain control before surgery in excess of systemic morphine equivalent to 10 mg\*
* Ejection fraction (EF) less than 30%
* Creatinine clearance less than 30 mL/min\*
* History of chronic liver failure
* Desire for nerve block or general anesthesia
* Any neurologic or psychiatric disorder (including bipolar disorder, post traumatic stress disorder, schizophrenia)
* Prior surgery on ipsilateral knee within the last 6 months
* Alcohol abuse
No
Sponsors
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Rothman Institute Orthopaedics
OTHER
Responsible Party
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Locations
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Rothman Institute
Philadelphia, Pennsylvania, United States
Countries
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Other Identifiers
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2016Levicoff
Identifier Type: -
Identifier Source: org_study_id
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