A Multicenter, Randomized, Placebo-Controlled, Double-Blind Study of SUN13834 in Adult Subjects With Atopic Dermatitis

NCT ID: NCT00717769

Last Updated: 2021-04-21

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

270 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-07-16

Study Completion Date

2009-04-09

Brief Summary

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The purpose of the study is to explore the efficacy and safety of SUN13834 vs placebo in adult participants with atopic dermatitis.

Detailed Description

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Conditions

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Atopic Dermatitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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SUN13834

Group Type EXPERIMENTAL

SUN13834

Intervention Type DRUG

Low dose, orally 3 times a day (tid) for 28 days of SUN13834

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Placebo, orally (tid) for 28 days of SUN13834

Interventions

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SUN13834

Low dose, orally 3 times a day (tid) for 28 days of SUN13834

Intervention Type DRUG

Placebo

Placebo, orally (tid) for 28 days of SUN13834

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Male or female participants between 18 and 65 years of age.
* A diagnosis of Atopic Dermatitis (AD), meeting the Guidelines for Diagnosis of Atopic Dermatitis criteria
* At least 1 inflammatory lesion Eczema Area and Severity Index (EASI) score ≥5 at Screening and prior to randomization (as per Amendment 2 and 3). Under the original protocol and Amendment 1, no minimum EASI score was required.

Exclusion Criteria

* Taking systemic immunosuppressive drugs or biologicals (within 3 months), or systemic corticosteroids therapy (within 4 weeks)prior to Screening(note: inhaled, intranasal or otic corticosteroids are allowed).
* Use of phototherapy or tanning beds within 6 weeks of screening
* History of reactive airway disease (asthma) requiring hospitalization in an intensive care unit in the last 5 years.
* Presence of a clinically significant disorder involving the cardiovascular, respiratory, renal, gastrointestinal, immunologic, hematologic, endocrine, or neurologic system(s) or psychiatric disease (as determined by the Clinical Investigator) that will interfere with the interpretation of data from this patient (eg, renal impairment with non-atopic pruritus).
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Daiichi Sankyo

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Global Clinical Leader

Role: STUDY_DIRECTOR

Daiichi Sankyo

Locations

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Radiant Research, Inc.

Birmingham, Alabama, United States

Site Status

Pivotal Research Center

Mesa, Arizona, United States

Site Status

Pivotal Research Center

Peoria, Arizona, United States

Site Status

Burke Pharmaceutical Research

Hot Springs, Arkansas, United States

Site Status

Therapeutics Clinical Research

San Diego, California, United States

Site Status

Horizons Clinical Research Center, LLC

Denver, Colorado, United States

Site Status

Miami Research Associates

Miami, Florida, United States

Site Status

Advanced Dermatology and Cosmetic Surgery

Ormond Beach, Florida, United States

Site Status

Stedman Clinical Trials

Tampa, Florida, United States

Site Status

Northwest Clinical Trials

Boise, Idaho, United States

Site Status

Deaconess Clinic Downtown Research Institute

Evansville, Indiana, United States

Site Status

DermResearch, PLLC

Louisville, Kentucky, United States

Site Status

Michigan Center for Skin Care Research

Clinton Township, Michigan, United States

Site Status

Academic Dermatology

Albuquerque, New Mexico, United States

Site Status

Derm Research Center of New York, Inc.

Stony Brook, New York, United States

Site Status

Wake Research Associates, LLC

Raleigh, North Carolina, United States

Site Status

Wake Forest University Health Sciences - Dermatology Studies

Winston-Salem, North Carolina, United States

Site Status

Toledo Center for Clinical Research

Sylvania, Ohio, United States

Site Status

Oklahoma University Health Sciences Center, Dermatology Dept

Oklahoma City, Oklahoma, United States

Site Status

Paddington Testing Co, Inc.

Philadelphia, Pennsylvania, United States

Site Status

Clinical Partners, LLC

Johnston, Rhode Island, United States

Site Status

Radiant Research, Inc

Greer, South Carolina, United States

Site Status

J & S Studies, Inc

College Station, Texas, United States

Site Status

Baylor Research Institute of Dermatology Department

Dallas, Texas, United States

Site Status

Dermatology Associates of San Antonio

San Antonio, Texas, United States

Site Status

Intermountain Clinical Research

Draper, Utah, United States

Site Status

Commonwealth Clinical Research Specialists, Inc.

Richmond, Virginia, United States

Site Status

Premier Clinical Research

Spokane, Washington, United States

Site Status

Countries

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United States

Other Identifiers

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ASBI 404

Identifier Type: -

Identifier Source: org_study_id

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