Histological Characterization and Differentiation of Rash From Other Epidermal Growth Factor Receptor (EGFR) Inhibitors

NCT ID: NCT00709878

Last Updated: 2015-03-17

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

32 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-04-30

Study Completion Date

2010-08-31

Brief Summary

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The purpose of this study is to characterize the microscopic findings of skin rash associated with the use of chemotherapeutic anticancer agents known as epidermal growth factor inhibitors (EGFRIs).

Detailed Description

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Epidermal growth factor (EGF) and its receptor, the EGFR, are known to be key drivers in cellular proliferation and survival. Malignant tumors result from uncontrolled cell proliferation. The use of drugs which target the EGF receptor has offered patients with non-small cell lung cancer, pancreatic cancer, head and neck cancer, and colorectal cancer additional targeted anti-cancer therapy in addition to their chemotherapeutic regimens. As a result of increased use of these EGFR inhibitors, adverse events have emerged involving the skin, hair, nails and eyes. While the EGFR inhibitors block the signal transduction that interfere with cellular proliferation and survival of cancerous cells, they also affect the normal EGF function in the skin (papulopustular rash), hair, and nails. In this study, we seek to histologically characterize the papulopustular rash in patients who have been treated with lapatinib and compare our findings with those associated with three other EGFRIs, cetuximab, erlotinib and panitumumab.

Conditions

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Skin Rash

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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L

Patients treated with lapatinib who developed skin toxicities and have been biopsied for skin rash.

Skin Biopsy of Skin Rash Secondary to EGFRI Use

Intervention Type PROCEDURE

Patients who were treated with lapatinib, cetuximab, panitumumab or erlotinib who subsequently developed a skin rash have been biopsied as standard of care. The biopsies will be used for this study.

C

Patients treated with cetuximab who developed skin toxicities and have been biopsied for skin rash.

Skin Biopsy of Skin Rash Secondary to EGFRI Use

Intervention Type PROCEDURE

Patients who were treated with lapatinib, cetuximab, panitumumab or erlotinib who subsequently developed a skin rash have been biopsied as standard of care. The biopsies will be used for this study.

P

Patients treated with panitumumab who developed skin toxicities and have been biopsied for skin rash.

Skin Biopsy of Skin Rash Secondary to EGFRI Use

Intervention Type PROCEDURE

Patients who were treated with lapatinib, cetuximab, panitumumab or erlotinib who subsequently developed a skin rash have been biopsied as standard of care. The biopsies will be used for this study.

E

Patients treated with erlotinib who developed skin toxicities and have been biopsied for a skin rash.

Skin Biopsy of Skin Rash Secondary to EGFRI Use

Intervention Type PROCEDURE

Patients who were treated with lapatinib, cetuximab, panitumumab or erlotinib who subsequently developed a skin rash have been biopsied as standard of care. The biopsies will be used for this study.

Interventions

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Skin Biopsy of Skin Rash Secondary to EGFRI Use

Patients who were treated with lapatinib, cetuximab, panitumumab or erlotinib who subsequently developed a skin rash have been biopsied as standard of care. The biopsies will be used for this study.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients treated with lapatinib who developed skin toxicities and were biopsied.
* Patients treated with erlotinib, cetuximab, or panitumumab who have been biopsied for skin rash.

Exclusion Criteria

* Patients who do not fit above criteria.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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GlaxoSmithKline

INDUSTRY

Sponsor Role collaborator

Northwestern University

OTHER

Sponsor Role lead

Responsible Party

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Northwestern University, Department of Dermatology

Principal Investigators

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Mario Lacouture, MD

Role: PRINCIPAL_INVESTIGATOR

Northwestern University, Department of Dermatology

Locations

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Northwestern University

Chicago, Illinois, United States

Site Status

Countries

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United States

References

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Reference Type RESULT
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Other Identifiers

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GSK-Lapatinib

Identifier Type: -

Identifier Source: org_study_id

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