Non-inferiority Clinic of Kollagenase® Compared Iruxol® in Treatment of Cutaneous Ulcers

NCT ID: NCT00701974

Last Updated: 2022-11-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

SUSPENDED

Clinical Phase

PHASE2/PHASE3

Total Enrollment

66 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-02-29

Study Completion Date

2008-02-29

Brief Summary

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Skin ulcers can be defined as open injuries, loss of substances with the skin or mucous tissue, caused by disintegration and tissue necrosis. Chronic skin ulcer is any injury that heal in a period not less than 6 weeks. Several etiological causes for the emergence of skin ulcers. Around 73% are venous, arterial are 8%, 3% are diabetic, 2% are traumatic and 14% are from other causes.

Clinical studies show that collagenase is an effective drug and presents high tolerabildade in the treatment of ulcerative burns and injuries of various etiologies. Evidence show statistically significant reduction of inflammation, the formation of granulation tissue, decrease in injuries and reepitelization.

Detailed Description

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Conditions

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Ulcers

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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1

patients treated with collagenase (IRUXOL)

Group Type EXPERIMENTAL

collagenase (IRUXOL)

Intervention Type BIOLOGICAL

patients will be treated with collagenase one time per day.

2

patients treated with collagenase (Kollagenase)

Group Type EXPERIMENTAL

collagenase (Kollagenase)

Intervention Type BIOLOGICAL

patients will be treated with collagenase one time per day.

Interventions

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collagenase (IRUXOL)

patients will be treated with collagenase one time per day.

Intervention Type BIOLOGICAL

collagenase (Kollagenase)

patients will be treated with collagenase one time per day.

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Patients of both sexes aged over 18 years
* people with skin ulcers of the lower limbs for at least 3 months

Exclusion Criteria

* Lesion with a diameter larger than 12 cm ²
* injury over 2 years of evolution; injury infected
* neoplastic lesions in activity
* poorly controlled diabetes mellitus
* HAS poorly controlled
* signs of ischemia in the limb
* not offset any disease
* allergic to components of formula
* urticaria
* pregnancy
* breastfeeding
* emotional disturbance
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Azidus Brasil

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Lal Clinica

Valinhos, São Paulo, Brazil

Site Status

Countries

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Brazil

Other Identifiers

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COLCRI0208

Identifier Type: OTHER

Identifier Source: secondary_id

COLCRI0208

Identifier Type: -

Identifier Source: org_study_id

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