Evaluate Efficacy and Safety of ChloraSolv When Treating Pressure Ulcers in Need of Debridement

NCT ID: NCT05547191

Last Updated: 2023-12-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

5 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-09-01

Study Completion Date

2023-11-20

Brief Summary

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This is an open, single-arm, multicentre and interventional investigation to evaluate the debriding effect of ChloraSolv when used on pressure ulcers in need of debridement. Approximately 54 subjects will be enrolled to have 47 evaluable subjects (calculated dropout range 15%).

ChloraSolv will be applied 1-2 times per week for 12 weeks or until the wound is deemed clean, whichever occurs first i.e. End of Treatment. A Follow-up visit for wound status evaluation will be performed 6 weeks from End of Treatment. Total time in investigation will be maximum 12+6 weeks.

Subjects will attend a baseline visit to assess eligibility and collect demographic and baseline data and initiate treatment. Photographs of the wound pre and post debridement will be taken at baseline, every week during the treatment period, at End of Treatment and at the Follow-up visit. Photographs will be used to calculate (by PictZar digital planimetry system) the area of devitalized tissue in the wound as well as wound size and calculation of volume.

Wound depth and undermining will be estimated by the investigator at all investigational visits.

A treatment diary will be used in-between the weekly investigational visits to collect any further treatments. The treatment diary will also be filled-in during the follow-up period of 6 weeks.

Detailed Description

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Conditions

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Pressure Ulcer

Keywords

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Pressure ulcer Debridement ChloraSolv

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Investigational device

ChloraSolv

Group Type EXPERIMENTAL

ChloraSolv

Intervention Type DEVICE

Debridement with ChloraSolv until the wound is visually assessed as clean.

Interventions

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ChloraSolv

Debridement with ChloraSolv until the wound is visually assessed as clean.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Pressure ulcer in need of debridement
2. Male or female, 18 years of age and above
3. Able to read and understand the Patient Informed Consent and to provide written informed consent. If written consent is not possible due to the condition of the patient, one impartial witness shall sign and date the informed consent.

Exclusion Criteria

1. Known allergy/hypersensitivity to any of the components of ChloraSolv
2. Pregnancy or breastfeeding
3. Subjects included in other ongoing clinical investigations which could interfere with this investigation, as judged by the investigator
4. Subjects not suitable for the investigation according to the investigator's judgment or other significant medical conditions that the investigator determines could interfere with compliance or investigation assessments
5. Wound requiring more than two (2) ChloraSolv syringes for one treatment
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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RLS Global

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Kirurgkliniken, Ålands hälso- och sjukvård

Mariehamn, Åland, Aland Islands

Site Status

Dept of Orthopaedic Surgery

Mölndal, , Sweden

Site Status

Buckinghamshire Healthcare NHS Trust

Aylesbury, England, United Kingdom

Site Status

Liverpool University Hospitals NHS Foundation Trust

Liverpool, England, United Kingdom

Site Status

East London NHS Foundation Trust

Newham, England, United Kingdom

Site Status

Greater Glasgow Health Board

Glasgow, Scotland, United Kingdom

Site Status

Countries

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Aland Islands Sweden United Kingdom

Other Identifiers

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320237

Identifier Type: REGISTRY

Identifier Source: secondary_id

PN-00041

Identifier Type: -

Identifier Source: org_study_id