Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
22 participants
INTERVENTIONAL
2007-07-31
2008-12-31
Brief Summary
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* exploring lorazepam (0.038 mg/kg) effects, after a single oral intake, in healthy volunteers, on the neural correlates of encoding and retrieval of information during a word-stem completion task (implicit memory), using fMRI
* comparing lorazepam effects to diazepam (0.3 mg/kg)effects
* exploring benzodiazepines effects, after a single oral intake, on the neural correlates of successful encoding of information within explicit memory using fMRI
Hypothesis :
* both diazepam and lorazepam will impair explicit memory performance, but lorazepam only will impair perceptual priming
* lorazepam and diazepam will modify the normal correlates of information encoding within explicit memory
* lorazepam only will alter the neural correlates of perceptual priming
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
OTHER
DOUBLE
Study Groups
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1
Oral Lorazepam
Lorazepam
Lorazépam drug (0,038 mg/kg) on a single oral intake
2
Oral Diazepam
Diazepam
Diazépam drug (0,3 mg/kg) on a single oral intake
3
Oral placebo
placebo
lorazépam placebo or Diazépam placebo
Interventions
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Diazepam
Diazépam drug (0,3 mg/kg) on a single oral intake
Lorazepam
Lorazépam drug (0,038 mg/kg) on a single oral intake
placebo
lorazépam placebo or Diazépam placebo
Eligibility Criteria
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Inclusion Criteria
* Students in medicine, dentistry or pharmacy
* French as a mother language
Exclusion Criteria
* Asthma
* General anesthesia in the 3 last months
* Drug addiction (DSM IV criteria)
* Regular medical treatment (except contraceptive pill)
* Significant impairment observed during a medical examination including ECG
* Intake of any psychotropic drug that can have a effect during testing
* IQ (Wechsler) \< 100
* FMRI contra-indication (implantable magnetic material, claustrophobia)
* Known allergy to benzodiazepine or lactose
* \> 10 cigarettes/day
* Pregnant or breast-feeding woman
* No health insurance
* Subjects who do not complete the entire study
18 Years
30 Years
ALL
Yes
Sponsors
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University Hospital, Strasbourg, France
OTHER
Responsible Party
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Principal Investigators
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Pierre Vidailhet, MD
Role: PRINCIPAL_INVESTIGATOR
Hôpitaux Universitaires de Strasbourg
Locations
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Centre d'investigation clinique, hôpital civil
Strasbourg, , France
Clinique psychiatrique, hôpital civil
Strasbourg, , France
Countries
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Other Identifiers
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3777
Identifier Type: -
Identifier Source: org_study_id
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