Positron Emission Tomography (PET) Study With (11C) Flumazenil to Determine Central GABAA Receptor Occupancy of AZD6280
NCT ID: NCT00681746
Last Updated: 2010-12-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE1
8 participants
INTERVENTIONAL
2008-02-29
2008-09-30
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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NON_RANDOMIZED
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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1
AZD6280
Single dose of oral solution or capsule(s). 3 times for the 2 subjects in Panel 1. Once for the 6 remaining subjects.
(11C) flumazenil
Single dose of intravenous solution. 4 times for 2 subjects in Panel 1. 2 times for the remaining 6 subjects. (once together with AZD6280)
Interventions
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AZD6280
Single dose of oral solution or capsule(s). 3 times for the 2 subjects in Panel 1. Once for the 6 remaining subjects.
(11C) flumazenil
Single dose of intravenous solution. 4 times for 2 subjects in Panel 1. 2 times for the remaining 6 subjects. (once together with AZD6280)
Eligibility Criteria
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Inclusion Criteria
* Clinically normal physical findings, medical history and laboratory values.
Exclusion Criteria
* History of clinically significant heart arrythmias or heart disease/problems.
* Previous participation in a PET study within the past 12 months. Suffer from claustrophobia and would be unable to undergo MRI (magnetic resonance imaging) or PET scanning.
20 Years
45 Years
MALE
Yes
Sponsors
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AstraZeneca
INDUSTRY
Responsible Party
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AstraZeneca Pharmaceuticals
Principal Investigators
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Bo Fransson
Role: PRINCIPAL_INVESTIGATOR
AstraZeneca Clinical Pharmacology Unit, Stockholm, Sweden
Eva Taavo
Role: STUDY_DIRECTOR
AstraZeneca R&D, Study Delivery, Clinical Development, Södertälje, Sweden
Locations
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Research Site
Stockholm, , Sweden
Countries
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References
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Jucaite A, Cselenyi Z, Lappalainen J, McCarthy DJ, Lee CM, Nyberg S, Varnas K, Stenkrona P, Halldin C, Cross A, Farde L. GABAA receptor occupancy by subtype selective GABAAalpha2,3 modulators: PET studies in humans. Psychopharmacology (Berl). 2017 Feb;234(4):707-716. doi: 10.1007/s00213-016-4506-4. Epub 2016 Dec 24.
Other Identifiers
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EudractCT 2007-006683-29
Identifier Type: -
Identifier Source: secondary_id
D0850C00011
Identifier Type: -
Identifier Source: org_study_id