Redox State in the Course of Chronic Renal Insufficiency and Hemodialysis: Implications in Morbimortality

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

131 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-06-30

Study Completion Date

2012-04-30

Brief Summary

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The influence of hemodialysis on oxidative stress, endothelial activation, inflammation and on the redox state of lymphocytes should be clarified as well as the putative relationships between all these parameters.

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Detailed Description

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Up to now, no anti-oxydative treatment has been able to reduce the mortality of the patients with Kidney Failure. Thus it is necessary to have a better knowledge of oxydative stress mechanisms in patients with KF in order to find more efficacious treatments. The influence of hemodialysis upon oxidative stress is not well known.

Conditions

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Chronic Renal Insufficiency

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Blinding Strategy

NONE

Study Groups

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1

Volunteer healthy

Group Type OTHER

Sampling of blood

Intervention Type OTHER

A sampling of blood will be made

2

Patient dialysis patient

Group Type OTHER

Sampling of blood

Intervention Type OTHER

A sampling of bood will be made before the dialysis

3

Not dialysed chronic renal insufficient patient

Group Type OTHER

Sampling of blood

Intervention Type OTHER

A sampling of blood will be made.

Interventions

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Sampling of blood

A sampling of blood will be made

Intervention Type OTHER

Sampling of blood

A sampling of bood will be made before the dialysis

Intervention Type OTHER

Sampling of blood

A sampling of blood will be made.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 18 and 80 years old man or woman dialysing at least 3 times a week for at least 6 months and having no residual renal function
* Rate of haemoglobin \> 11 g / dl
* Clinically stable patient that is having had no considerable event (cardiovascular problem, infection, surgical operation) with the exception of angioplasty of fistula or prosthesis vascular, in the previous 3 months the entrance to the study
* Patient capable of understanding and of following the essay, in particular knowing how to read the note of information.

Exclusion Criteria

* Pregnant woman
* Treatment by corticoids or immunosuppresseurs
* hemopathy sly
* chronic cancer or infection in evolution
* Cardiovascular event (infarct, unstable angor, coronary bypasses, confusions of the rhythm, AVC, amputation) or infectious (blood-poisoning, pneumopathie, meningitis) or surgical operation in the previous 3 months the inclusion in the study.

Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes