Transoral Gastric Volume Reduction as an Intervention for Weight Management

NCT ID: NCT00679848

Last Updated: 2017-01-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

18 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-05-31

Study Completion Date

2010-11-30

Brief Summary

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The purpose of this study is to evaluate the safety, technical feasibility, and initial effectiveness (i.e., weight loss primarily measured as percent excess weight loss) of TGVR performed using the Bard RESTORe Suturing System

Detailed Description

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Conditions

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Obesity

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Transoral Suturing

Group Type EXPERIMENTAL

RS2 (RESTORe Suturing System)

Intervention Type DEVICE

Suturing in stomach

Interventions

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RS2 (RESTORe Suturing System)

Suturing in stomach

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Male, Female; ages \>18yrs - £ 60 yrs
* BMI 30-45 kg/m2
* History of obesity for 5 yrs; attempts at weight control ineffective
* Weight stable
* Willing to comply with study requirements
* Agrees to not have any additional weight loss surgery, reconstructive surgery or liposuction for one year following procedure
* Sign informed consent form

Exclusion Criteria

* Women of childbearing age not practicing effective birth control method or pregnant or lactating
* Mallampati score = 4
* Uncontrolled hypothyroidism
* Previous interventional/surgical treatment of obesity; any prior gastric surgery
* History of diabetes for \> 10 yrs or difficult to control diabetes
* Presence of hiatal hernia
* Congenital or acquired anomalies of the GI tract
* Severe cardiovascular, cerebrovascular, or cardiopulmonary disease
* Chronic or acute upper gastrointestinal bleeding conditions
* Helicobacter pylori positive
* Immunocompromised
* Subjects with eating disorders
* Acute or chronic infection
* Significant movement limitations
* Not a candidate for conscious or general anesthesia
* Active substance abuse
* Life expectancy \< 2 years
* Enrolled in another investigational drug or device trial that has not completed the primary endpoint or that clinically interferes with this study
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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C. R. Bard

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Brigham and Women's Hospital

Boston, Massachusetts, United States

Site Status

Cleveland Clinic

Cleveland, Ohio, United States

Site Status

Countries

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United States

Other Identifiers

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DVL-EC-003

Identifier Type: -

Identifier Source: org_study_id

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