Investigation of Antipsoriatic Effects of UVB-induced Synthesis of 1alpha, 25-Dihydroxyvitamin D3 (1alpha, 25(OH)2D3, Calcitriol)in Keratinocytes of Psoriatic Skin, Using Cytochrom-P(CYP)Inhibitor Ketokonazol
NCT ID: NCT00678756
Last Updated: 2010-06-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE2
12 participants
INTERVENTIONAL
2008-03-31
2009-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
TREATMENT
NONE
Interventions
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Ketokonazol 2% cream
twice a day at 2 times,2 out of 5 areas have to be treated for 4 weeks/7 days a week
UVB-radiation 311nm
3 out of 5 areas are radiated for 4 weeks every MO/DI/DO/FR starting MED orientated, intensified everytime 0,03 J/qcm
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* diagnosis of psoriasis vulgaris (mild- middle)
* no other current antipsoriatic therapy (systemic/topical)
* at least 5 psoriatic areas of 5x5 cm
Exclusion Criteria
* women in reproductive age without adequate contraception
* severe and acute forms of psoriasis vulgaris
* patients receiving systemic or topical antipsoroatic treatment in past 3 month
* UV-therapy in past 3 month
* patients having a positive anamnesis for squamous cell carcinoma, malignant melanoma, basalioma
* epilepsy
18 Years
80 Years
ALL
No
Sponsors
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Technische Universität Dresden
OTHER
Responsible Party
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Technical University Dresden, Department of Dermatology
Principal Investigators
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Gottfried Wozel, Prof. Dr.med
Role: PRINCIPAL_INVESTIGATOR
Department of Dermatology, Medical Faculty, Technical University Dresden, Germany
Locations
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Department of Dermatology, Medical Faculty, TU Dresden
Dresden, , Germany
Countries
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Other Identifiers
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TUD-VITAKET
Identifier Type: -
Identifier Source: org_study_id
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