Resolvin D1 in Psoriasis Before and After Narrowband UVB Phototherapy

NCT ID: NCT03483311

Last Updated: 2018-03-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-03-01

Study Completion Date

2018-09-30

Brief Summary

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• Assessment of tissue level of resolvin D1 in psoriasis in comparison to its level in healthy controls in order to verify its role in the pathogenesis of psoriasis.

Detailed Description

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Conditions

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Psoriasis

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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psoriasis patients

Tissue levels of resolvin D1 in psoriatic patients before and after NB-UVB.

Group Type EXPERIMENTAL

skin biopsy before and after NB-UVB phototherapy

Intervention Type OTHER

skin biopsy before and after NB-UVB phototherapy to measure tissue resolvin D1

controls

Tissue levels of resolvin D1 in controls

Group Type EXPERIMENTAL

skin biopsy before and after NB-UVB phototherapy

Intervention Type OTHER

skin biopsy before and after NB-UVB phototherapy to measure tissue resolvin D1

Interventions

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skin biopsy before and after NB-UVB phototherapy

skin biopsy before and after NB-UVB phototherapy to measure tissue resolvin D1

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients with psoriasis (adults and children above 12years)
* Both sexes.
* New cases or cases not receiving any treatment for at least 3 months ago.

Exclusion Criteria

* Any contraindication to phototherapy treatment (e.g. Photosensitizing creams or medications, past skin cancer, especially melanoma, etc...)
* Erythrodermic and pustular psoriasis.
* History of autoimmune diseases or other systemic diseases (e.g. Alzheimer's disease, fibromyalgia, cystic fibrosis)
Minimum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Cairo University

OTHER

Sponsor Role lead

Responsible Party

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Maha Fathy Elmasry

principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Maha Elmasry

Role: PRINCIPAL_INVESTIGATOR

Cairo University

Locations

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Maha Fathy Elmasry

Cairo, , Egypt

Site Status RECRUITING

Countries

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Egypt

Central Contacts

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Maha Fathy Elmasry, MD

Role: CONTACT

Phone: 01222633740

Email: [email protected]

Facility Contacts

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Maha Fathy Elmasry, MD

Role: primary

References

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Elmasry MF, Hassan E, Rashed LA, Abdel Halim DM. Role of resolvin D1 in psoriasis before and after narrowband ultraviolet B phototherapy: A case-control study. Dermatol Ther. 2021 Mar;34(2):e14879. doi: 10.1111/dth.14879. Epub 2021 Feb 21.

Reference Type DERIVED
PMID: 33586174 (View on PubMed)

Other Identifiers

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Dermatology7

Identifier Type: -

Identifier Source: org_study_id