Surgical Treatment To Greater Anterior Vaginal Prolapse

NCT ID: NCT00676325

Last Updated: 2008-05-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE4

Total Enrollment

70 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-01-31

Study Completion Date

2009-12-31

Brief Summary

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A RCT study to compare traditional colporrhaphy versus polypropylene mesh in treatment of the anterior vaginal wall prolapse.

Detailed Description

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Seventy patients with greater anterior vaginal prolapse, whit stress incontinence or not, were randomly assigned to either colporrhaphy or polypropylene mesh repair( NAZCA TC™ POP REPAIR SYSTEM) . The primary outcome was recurrent anterior vaginal prolapse, and secondary outcomes were effects on quality of life and sexual symptom scores, operative time, length of hospitalization, and adverse events.

Conditions

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Hernia Cystocele

Keywords

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anterior vaginal prolapse traditional treatment mesh, graft NAZCA TC™ POP REPAIR SYSTEM colporrhaphy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Investigators Outcome Assessors

Study Groups

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1

Women 50 years and older with greater anterior vaginal prolapse,whit stress incontinence or not, requiring surgical correction were eligible for participation.traditional colporrhaphy in this group.

Group Type ACTIVE_COMPARATOR

Surgical treatment of Anterior Vaginal Prolapse

Intervention Type PROCEDURE

seventy patients with greater anterior vaginal prolapse, whit stress incontinence or not, were randomly assigned to either colporrhaphy or polypropylene mesh repair (NAZCA TC™ POP REPAIR SYSTEM ) . The primary outcome was recurrent anterior vaginal prolapse, and secondary outcomes were effects on quality of life and sexual symptom scores, operative time, blood loss, length of hospitalization, and adverse events.

NAZCA TC™ POP REPAIR SYSTEM ,promedon® , argentina.

Intervention Type DEVICE

Women 50 years and older with greater anterior vaginal prolapse,whit stress incontinence or not, requiring surgical correction .

2

The NAZCA TC™ POP REPAIR SYSTEM (polypropylene mesh repair),promedon™ , cordoba, argentina, is used to repair anterior vaginal prolapse by a transobturator and pre pubic approach . Helical needles are used to anchor graft to the pelvic sidewall at two points transobturator, the other two arms pre pubic needles is used. We designed this randomized control trial to compare the anatomic success rates, effect on quality of life and sexual symptom scores, and rates of adverse events of the procedure with polypropylene mesh with that of anterior colporrhaphy, with planned follow-up of 1 years.

Group Type ACTIVE_COMPARATOR

Surgical treatment of Anterior Vaginal Prolapse

Intervention Type PROCEDURE

seventy patients with greater anterior vaginal prolapse, whit stress incontinence or not, were randomly assigned to either colporrhaphy or polypropylene mesh repair (NAZCA TC™ POP REPAIR SYSTEM ) . The primary outcome was recurrent anterior vaginal prolapse, and secondary outcomes were effects on quality of life and sexual symptom scores, operative time, blood loss, length of hospitalization, and adverse events.

NAZCA TC™ POP REPAIR SYSTEM ,promedon® , argentina.

Intervention Type DEVICE

Women 50 years and older with greater anterior vaginal prolapse,whit stress incontinence or not, requiring surgical correction .

surgical treatment for anterior vaginal wall prolapse

Intervention Type PROCEDURE

Women 50 years and older with greater anterior vaginal prolapse,whit stress incontinence or not requiring surgical correction were eligible for participation.

Interventions

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Surgical treatment of Anterior Vaginal Prolapse

seventy patients with greater anterior vaginal prolapse, whit stress incontinence or not, were randomly assigned to either colporrhaphy or polypropylene mesh repair (NAZCA TC™ POP REPAIR SYSTEM ) . The primary outcome was recurrent anterior vaginal prolapse, and secondary outcomes were effects on quality of life and sexual symptom scores, operative time, blood loss, length of hospitalization, and adverse events.

Intervention Type PROCEDURE

NAZCA TC™ POP REPAIR SYSTEM ,promedon® , argentina.

Women 50 years and older with greater anterior vaginal prolapse,whit stress incontinence or not, requiring surgical correction .

Intervention Type DEVICE

surgical treatment for anterior vaginal wall prolapse

Women 50 years and older with greater anterior vaginal prolapse,whit stress incontinence or not requiring surgical correction were eligible for participation.

Intervention Type PROCEDURE

Other Intervention Names

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traditional colporraphy anterior vaginal wall polypropylene mesh - NAZCA TC™ POP REPAIR SYSTEM traditional colporraphy NAZCA TC™ POP REPAIR SYSTEM

Eligibility Criteria

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Inclusion Criteria

* Women 50 years and older with greater anterior vaginal prolapse,whit stress incontinence or not,point (Ba)ics96, below hymenal ring requiring surgical correction were eligible for participation.

Exclusion Criteria

Patients were excluded if they had:

* Stage 0 or I (ics96) anterior vaginal support
* Declined participation
* Were pregnant or contemplating future pregnancy
* Had prior anterior vaginal prolapse repair with biologic or synthetic graft
* Active or latent systemic infection
* Compromised immune system
* Uncontrolled diabetes mellitus,
* Previous pelvic irradiation or cancer
* Known hypersensitivity to polypropylene.
Minimum Eligible Age

50 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Federal University of São Paulo

OTHER

Sponsor Role lead

Responsible Party

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federal university of sao paulo- unifesp

Principal Investigators

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carlos a del roy, M D

Role: PRINCIPAL_INVESTIGATOR

Federal University of São Paulo

Locations

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Sao Paulo Hospital

São Paulo, São Paulo, Brazil

Site Status

Countries

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Brazil

References

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Riccetto C, Miyaoka R, de Fraga R, Barbosa R, Dambros M, Teixeira A, Palma P. Impact of the structure of polypropylene meshes in local tissue reaction: in vivo stereological study. Int Urogynecol J Pelvic Floor Dysfunct. 2008 Aug;19(8):1117-23. doi: 10.1007/s00192-008-0582-2. Epub 2008 Mar 20.

Reference Type RESULT
PMID: 18351281 (View on PubMed)

Related Links

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http://www.iuga.org

INTERNATIONAL UROGYNECOLOGICAL ASSOCIATION

Other Identifiers

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unifespcep 1790/06

Identifier Type: -

Identifier Source: org_study_id