A Phase I Study of LBH589 (Panobinostat) in Combination With External Beam Radiotherapy for the Treatment of Prostate Cancer, Esophageal Cancer and Head and Neck Cancer

NCT ID: NCT00670553

Last Updated: 2017-05-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

7 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-09-30

Study Completion Date

2010-01-31

Brief Summary

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The purpose of this study is to assess the feasibility of combined administration of different LBH589 dosages with radiotherapy in order to establish the dosage to be evaluated in future studies.

Detailed Description

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Conditions

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Prostate Cancer Head & Neck Cancer Esophageal Cancer

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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LBH589

Group Type EXPERIMENTAL

panobinostat

Intervention Type DRUG

Interventions

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panobinostat

Intervention Type DRUG

Other Intervention Names

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LBH589

Eligibility Criteria

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Inclusion Criteria

* Patients with age ≥18 years
* Confirmed diagnosis of prostate cancer, SCC esophageal cancer or head \& neck cancer
* No evidence of distant spread of the disease

Exclusion Criteria

* Patients who have severe and/or uncontrolled medical conditions
* Female patients who are pregnant or breast feeding
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Novartis Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Novartis Pharmaceuticals

Role: STUDY_DIRECTOR

Novartis Pharmaceuticals

Locations

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Novartis Investigative Site

Liège, , Belgium

Site Status

Countries

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Belgium

Other Identifiers

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CLBH589CBE01

Identifier Type: -

Identifier Source: org_study_id

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