Is Pentoxifylline Able to Improve Olfactory Sensitivity?

NCT ID: NCT00660868

Last Updated: 2016-02-05

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 7 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2009-11-30
• Study Completion Date: 2016-01-31

Brief Summary

Signal processing in the olfactory neuron could be influenced by inhibition of enzymes like phosphodiesterase. Pentoxifylline is a unspecific phosphodiesterase inhibitor. The hypothesis is that pentoxifylline could lead to increased sensitivity to odors.

Detailed Description

Olfactory signal processing is conducted by a G-protein linked increase of intracellular concentration of adenosine 3´,5´-cyclic monophosphate (cAMP). In the cilia of olfactory sensory neurons (OSN) cAMP is degraded by phosphodiesterase 1C2 (PDE1C2). Inhibition of PDE1C2 could result in an increased response of OSN to chemical stimuli. Aim of the present prospective post-marketing surveillance study was to investigate the impact of pentoxifylline, an unspecific phosphodieasterase inhibitor, on olfactory function.

Conditions

Olfaction Disorders

Study Design

• Study Time Perspective: PROSPECTIVE

Study Groups

1

Patients with posttraumatic, idiopathic, and postinflammatory cause of smell loss; patients age between 18 and 50 years. Odor threshold better than 1.

Pentoxifylline retard 400mg

Intervention Type: DRUG

Agapurin retard 400mg 3/day per os for 3 weeks

Interventions

Pentoxifylline retard 400mg

Agapurin retard 400mg 3/day per os for 3 weeks

Intervention Type: DRUG

Other Intervention Names

Agapurin retard

Eligibility Criteria

Inclusion Criteria

• hyposmic or functionally anosmic patients TDI-score <31
• age: 18-50 years
• odor threshold: better than 1
• cause of smell loss: post traumatic, postinflammatory, idiopathic

Exclusion Criteria

• normosmic patients,
• patients with contraindications for application of pentoxifylline
• patients that cannot give written agreement to the study
• patients under 18 years and over 50 years of age

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Technische Universität Dresden

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Volker Gudziol, Dr. med.

Role: PRINCIPAL_INVESTIGATOR

Technische Universität Dresden

Locations

Zentrum für Riechen und Schmecken, Universitäts- HNO- Klinik Dresden

Dresden, , Germany

Countries

Germany

Other Identifiers

EK157072007

Identifier Type: -

Identifier Source: org_study_id