Long-term Extension Study Evaluating Extended Release Ropinirole XL (Formerly Referred to as Ropinirole CR) in Patients Who Already Completed Either Study 167 or 164

NCT ID: NCT00650104

Last Updated: 2013-05-06

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

76 participants

Study Classification

INTERVENTIONAL

Study Start Date

2002-05-31

Study Completion Date

2009-03-31

Brief Summary

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The purpose of this study is to obtain information on the long-term safety, tolerability, and therapeutic benefit of extended release ropinirole XL, and to provide a mechanism for patients who participated in either Study 167 or Study 164 to continue receiving ropinirole XL if they chose to do so.

Detailed Description

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Conditions

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Parkinson Disease

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Active

Open label medication - Ropinirole CR

Group Type ACTIVE_COMPARATOR

Ropinirole XL (formerly CR)

Intervention Type DRUG

Active Ropinirole CR tablets of 2.0mg, 4.0mg, 8.0mg where subjects can tritrate to an stable optimum dose level of either 2.0mg, 4.0mg, 6.0mg, 8.0mg, 12mg, 16mg, 20mg, or 24mg per day.

Interventions

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Ropinirole XL (formerly CR)

Active Ropinirole CR tablets of 2.0mg, 4.0mg, 8.0mg where subjects can tritrate to an stable optimum dose level of either 2.0mg, 4.0mg, 6.0mg, 8.0mg, 12mg, 16mg, 20mg, or 24mg per day.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Males or non-pregnant/non-breast feeding females
* At least 30 years of age
* Diagnosis of idiopathic Parkinson''s disease (Hoehn \& Yahr criteria)
* Completed either Study 167 or Study 164

Exclusion Criteria

* Presence of uncontrolled psychiatric, hematological, renal, hepatic,endocrinological, neurological, cardiovascular disease or active malignancy
* Dizziness or fainting due to orthostatic hypotension on standing
* Significant sleep disorder
* Drug abuse or alcoholism
Minimum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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GlaxoSmithKline

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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GSK Clinical Trials

Role: STUDY_DIRECTOR

GlaxoSmithKline

Locations

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GSK Investigational Site

Scottsdale, Arizona, United States

Site Status

GSK Investigational Site

Los Angeles, California, United States

Site Status

GSK Investigational Site

Oxnard, California, United States

Site Status

GSK Investigational Site

Miami, Florida, United States

Site Status

GSK Investigational Site

Tampa, Florida, United States

Site Status

GSK Investigational Site

Augusta, Georgia, United States

Site Status

GSK Investigational Site

Kansas City, Kansas, United States

Site Status

GSK Investigational Site

Edison, New Jersey, United States

Site Status

GSK Investigational Site

Upland, Pennsylvania, United States

Site Status

GSK Investigational Site

Houston, Texas, United States

Site Status

Countries

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United States

References

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Hauser RA, Reichmann H, Lew M, Asgharian A, Makumi C, Shulman KJ. Long-term, open-label study of once-daily ropinirole prolonged release in early Parkinson's disease. Int J Neurosci. 2011 May;121(5):246-53. doi: 10.3109/00207454.2010.546538. Epub 2011 Jan 19.

Reference Type BACKGROUND
PMID: 21244307 (View on PubMed)

Other Identifiers

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101468/196

Identifier Type: -

Identifier Source: org_study_id

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