Substrate Metabolism and Insulin Sensitivity in Acromegalic Patients Before and After Treatment

NCT ID: NCT00647179

Last Updated: 2017-12-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

27 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-02-29

Study Completion Date

2016-12-07

Brief Summary

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The purpose of this study is to investigate the effects of chronic elevated growth hormone on metabolism and insulin sensitivity by studying acromegalic patients before and after treatment.

Detailed Description

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Conditions

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Acromegaly Excessive Growth Hormone Secretion Insulin Resistance

Keywords

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Acromegaly Growth Hormone Insulin resistance Glucose tolerance Body Composition Substrate metabolism

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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1

Patients recently diagnosed with acromegaly

Transsphenoidal adenomectomy

Intervention Type PROCEDURE

Surgery

Interventions

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Transsphenoidal adenomectomy

Surgery

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Written consent
* Age between 18 and 70
* Recently diagnosed with acromegaly

Exclusion Criteria

* NYHA 3
* Uncontrolled hypertension
* Known cerebrovascular disease
* Proliferative retinopatia
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Aarhus University Hospital

OTHER

Sponsor Role collaborator

University of Aarhus

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jens Otto L. Jørgensen, Professor MD

Role: PRINCIPAL_INVESTIGATOR

Aarhus University Hospital, Department of Endocrinology

Locations

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Department of Endocrinology, Aarhus University Hospital

Aarhus C, Aarhus, Denmark

Site Status

Countries

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Denmark

References

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Arlien-Soborg MC, Grondahl C, Baek A, Dal J, Madsen M, Hogild ML, Pedersen SB, Bjerre M, Jorgensen JOL. Fibroblast Activation Protein is a GH Target: A Prospective Study of Patients with Acromegaly Before and After Treatment. J Clin Endocrinol Metab. 2020 Jan 1;105(1):dgz033. doi: 10.1210/clinem/dgz033.

Reference Type DERIVED
PMID: 31544947 (View on PubMed)

Other Identifiers

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M-20070130

Identifier Type: -

Identifier Source: secondary_id

MM-ISA-20070130

Identifier Type: -

Identifier Source: org_study_id