The Incretin Effect in Patients With Chronic Pancreatitis

NCT ID: NCT00638573

Last Updated: 2010-01-13

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 32 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2006-01-31
• Study Completion Date: 2006-07-31

Brief Summary

The phenomenon that oral glucose elicits a higher insulin response than does intravenous (iv) glucose, even at identical plasma glucose (PG) profiles (isoglycemia), is called the incretin effect. In type 2 diabetes mellitus (T2DM) the incretin effect has been shown to be markedly reduced or even abolished. It is not known whether the reduced incretin effect in T2DM is a primary event leading to T2DM or if it is merely a consequence of the diabetic state. To answer this question the investigators plan to estimate the incretin effect in 8 patients with secondary diabetes mellitus (DM) to chronic pancreatitis (CP) and compare it to the incretin effect of 8 patients with CP and normal glucose tolerance (NGT). Eight patients with T2DM and 8 healthy control subjects are studied for comparison. The incretin effect is measured by a 50-g oral glucose tolerance test and an isoglycemic intravenous glucose infusion.

Conditions

Chronic Pancreatitis; Type 2 Diabetes Mellitus

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Eligibility Criteria

Inclusion Criteria

• Diagnosis of chronic pancreatitis with secondary diabetes mellitus
• Diagnosis of chronic pancreatitis with normal glucose tolerance
• Diagnosis of type 2 diabetes
• Normal level of hemoglobin
• Normal level of se-creatinine

Exclusion Criteria

• GAD-65 autoantibodies
• ICA autoantibodies
• Albuminuria

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Copenhagen

OTHER

Sponsor Role: collaborator

University Hospital, Gentofte, Copenhagen

OTHER

Sponsor Role: lead

Responsible Party

Diabetes Research Division, Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen

Principal Investigators

Filip K Knop, MD

Role: PRINCIPAL_INVESTIGATOR

University of Copenhagen

Jens J Holst, MD DMSc

Role: STUDY_DIRECTOR

University of Copenhagen

Thure Krarup, MD DMSc

Role: STUDY_DIRECTOR

Gentofte University Hospital

Locations

Gentofte University Hospital

Hellerup, Copenhagen County, Denmark

Countries

Denmark

Other Identifiers

KA04034

Identifier Type: -

Identifier Source: org_study_id