Effects of Infliximab on Insulin Sensitivity and Beta Cell Function in Insulin Resistant Human Obesity

NCT ID: NCT00636142

Last Updated: 2008-03-14

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE4
• Total Enrollment: 9 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2005-09-30
• Study Completion Date: 2007-09-30

Brief Summary

The aim of the study is to test whether neutralizing TNF-alpha with infliximab affects insulin resistance and phenotypical manifestations of the metabolic syndrome as fasting plasma insulin, total body fat, plasma lipid profile or vascular endothelial function in obese male subjects.

Detailed Description

Overweight and obesity are rapidly becoming one of the most pressing health problems. Obese subjects face an increased risk for cardiovascular events that is closely related to a cluster of metabolic disturbances (i.e. insulin resistance, hypertension, dyslipidemia and impaired fibrinolysis), collectively referred to as syndrome X. The actual mechanism underlying development of syndrome X has not been elucidated. Increased TNF-alpha activity has been proposed as a key factor.

The objectives of the study are to test whether neutralizing TNF-alpha with infliximab in obese subjects affects insulin resistance and phenotypical manifestations of the metabolic syndrome such as:

• fasting plasma insulin
• ivGTT derived parameters of insulin resistance and beta-cell function
• total body fat
• plasma lipid profile
• vascular endothelial dysfunction

Conditions

Obesity; Insulin Resistance; Metabolic Syndrome

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

1

Infliximab

Group Type: ACTIVE_COMPARATOR

Infliximab

Intervention Type: BIOLOGICAL

5 mg/kg body weight, maximal dose 500 mg; intravenous administration

2

Placebo

Group Type: PLACEBO_COMPARATOR

Infliximab

Intervention Type: BIOLOGICAL

5 mg/kg body weight, maximal dose 500 mg; intravenous administration

Interventions

Infliximab

5 mg/kg body weight, maximal dose 500 mg; intravenous administration

Intervention Type: BIOLOGICAL

Other Intervention Names

Remicade; EU/1/99/116/001-003

Eligibility Criteria

Inclusion Criteria

• Men, 20-50 years
• BMI 30-35 kg/m2
• HOMA index > 2.5
• stable weight (+/- 2 kg) > 3 months
• Blood pressure>135/85 mmHg (or treated hypertension)
• Triglycerides>1.7 mmol/l or HDL-cholesterol<1.3 mmol/l

Adequate birth control measures for the duration of the study and should continue such precautions for 6 months after receiving the last infusion.

Hemoglobin >= 8.5 g/dL WBC >= 3.5 x 109/L Neutrophils >= 1.5 x 109/L Platelets >= 100 x 109/L SGOT (AST) and AP <3xULN

Chest radiograph within 3 months prior to first infusion with no evidence of malignancy, infection or fibrosis.

No history of latent or active TB prior to screening. No signs or symptoms suggestive of active TB upon medical history and/or physical examination.

No recent close contact with a person with active TB or, if there has been such contact, will be referred to a physician specializing in TB to undergo additional evaluation and, if warranted, receive appropriate treatment for latent TB prior to or simultaneously with the first administration of study agent.

Within 1 month prior to the first administration of study agent, either have a negative tuberculin skin test or have a newly identified positive tuberculin skin test during screening in which active TB has been ruled out and for which appropriate treatment for latent TB has been initiated either prior to or simultaneously with the first administration of study agent Have a chest radiograph taken within 3 months prior to the first administration of study agent with no evidence of current active TB or old inactive TB.

Exclusion Criteria

• Overt Diabetes mellitus
• Current treatment with angiotensin II antagonists or ACE inhibitors.
• Treatment indication with statins according to the current NCEP III criteria.
• Treatment indication with low dose acetylsalicylic acid according to the current AHA guidelines or any other NSAID.
• Current smokers.
• Patients with (a history of) an autoimmune disease.
• Use of any investigational drug within 1 month prior to screening or within 5 half-lives of the investigational agent, whichever is longer.
• Treatment with any other therapeutic agent targeted at reducing TNFα within 3 months of screening.
• Previous administration of infliximab.
• History of receiving human/murine recombinant products or known allergy to murine products.
• Serious infections (such as pneumonia or pyelonephritis) in the previous 3 months. Less serious infections (such as acute upper respiratory tract infection [colds] or simple urinary tract infection) need not be considered exclusions at the discretion of the investigator.
• Documented HIV infection.
• Active hepatitis- B or antibodies against hepatitis-C
• History of latent or active granulomatous infection, including TB, histoplasmosis, or coccidioidomycosis, prior to screening.
• Have or have had a opportunistic infection within 6 months prior to screening.
• Have current signs or symptoms of severe, progressive or uncontrolled renal, hepatic, hematologic, gastrointestinal, endocrine, pulmonary, cardiac, neurologic, or cerebral disease (including demyelinating diseases such as multiple sclerosis).
• Concomitant congestive heart failure, including medically controlled asymptomatic patients.
• Presence of a transplanted organ
• Malignancy within the past 5 years.
• History of lymphoproliferative disease including lymphoma, or signs and symptoms suggestive of possible lymphoproliferative disease, such as lymphadenopathy of unusual size or location or splenomegaly.
• Known recent substance abuse (drug or alcohol).
• Have had a Bacille Calmette-Guerin (BCG) vaccination within 12 months of screening.
• Have a chest radiograph within 3 months prior to randomization that shows an abnormality suggestive of a malignancy or current active infection, including TB.

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: No

Sponsors

Medical University of Graz

OTHER

Sponsor Role: lead

Responsible Party

Department of Internal Medicine, Medical University of Graz

Principal Investigators

Thomas C. Wascher, MD

Role: PRINCIPAL_INVESTIGATOR

Medical University of Graz, Graz, Austria

Locations

Department of Internal Medicine, Medical University of Graz

Graz, , Austria

Countries

Austria

References

Wascher TC, Lindeman JH, Sourij H, Kooistra T, Pacini G, Roden M. Chronic TNF-alpha neutralization does not improve insulin resistance or endothelial function in "healthy" men with metabolic syndrome. Mol Med. 2011 Mar-Apr;17(3-4):189-93. doi: 10.2119/molmed.2010.00221. Epub 2010 Nov 16.

Reference Type: DERIVED

PMID: 21103669 (View on PubMed)

Other Identifiers

2005-000181-39

Identifier Type: -

Identifier Source: org_study_id