An Eval of Neurocognitive Function, Oxidative Damage, and Their Association With Outcomes in METH and Cocaine Abusers.
NCT ID: NCT00628927
Last Updated: 2015-12-30
Study Results
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View full resultsBasic Information
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COMPLETED
217 participants
OBSERVATIONAL
2008-02-29
2010-03-31
Brief Summary
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Detailed Description
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1. performance on various neurocognitive measures, including the Stroop, Rey Auditory-Verbal Learning Test (RAVLT), Iowa Gambling Task (GT), Wisconsin Card Sorting Task (WCST), the Barratt Impulsiveness Scale version -11 (BIS-11), and the Frontal Systems Behavior Scale (FrSBe) is predictive of treatment attrition and stimulant use outcomes in METH/cocaine abusers;
2. neurocognitive test performance is associated with oxidative damage, a severe consequence of oxidative stress, in METH/cocaine abusers;
3. oxidative damage is predictive of treatment attrition and substance use outcomes in METH/cocaine abusers,
4. oxidative damage in METH/cocaine abusers is significantly greater than that of a normal comparison group and
5. exploratory analyses reveal a significant relationship among oxidative stress, neurocognitive function, and treatment outcomes in METH/cocaine abusers.
Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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METH and/or cocaine dependent group
The METH and/or cocaine dependent group were also enrolled in CTN0031 (NCT00573183) and seeking treatment. This group will be analyzed based on whether or not they completed treatment as defined by the study.
No interventions assigned to this group
Non METH and/or cocaine dependent group
The Non METH and/or cocaine dependent group participants are normal controls recruited from the community.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* current abuse or dependence for METH and/or cocaine
* endorse METH and/or cocaine as the primary drug of choice
* able to correctly distinguish the colored stimuli on the Stoop task.
* be 18 years of age or older
* be able to understand the study and provide written informed consent in English
Exclusion Criteria
* history of a seizure disorder
* history of stroke
* history of a seizure disorder
* positive urine toxicology screen
* screen positive for Major Depressive Syndrome, other Depressive Syndrome, Panic Syndrome, or other Anxiety Syndrome
* meet criteria for ADHD
* have HIV/AIDS
* history of an injury in which consciousness was lost for more than 30 minutes
* meet DSM-IV criteria for dependence (either current or lifetime) for any psychoactive substance other than nicotine or for abuse (both current and lifetime) for any psychoactive substance other than nicotine or for alcohol for which a life-time history of abuse is allowed
18 Years
99 Years
ALL
No
Sponsors
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National Institute on Drug Abuse (NIDA)
NIH
University of Cincinnati
OTHER
Responsible Party
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Theresa Winhusen
Associate Professor
Principal Investigators
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Theresa Winhusen, Ph.D.
Role: PRINCIPAL_INVESTIGATOR
University of Cincinnati
Locations
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Gateway Community Services
Jacksonville, Florida, United States
Maryhaven
Columbus, Ohio, United States
Willamette Family Treatment Services
Eugene, Oregon, United States
ChangePoint, Inc.
Portland, Oregon, United States
Nexus Recovery Center
Dallas, Texas, United States
Recovery Centers of King County
Seattle, Washington, United States
Countries
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References
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Winhusen TM, Somoza EC, Lewis DF, Kropp FB, Horigian VE, Adinoff B. Frontal systems deficits in stimulant-dependent patients: evidence of pre-illness dysfunction and relationship to treatment response. Drug Alcohol Depend. 2013 Jan 1;127(1-3):94-100. doi: 10.1016/j.drugalcdep.2012.06.017. Epub 2012 Jul 6.
Winhusen T, Walker J, Brigham G, Lewis D, Somoza E, Theobald J, Somoza V. Preliminary evaluation of a model of stimulant use, oxidative damage and executive dysfunction. Am J Drug Alcohol Abuse. 2013 Jul;39(4):227-34. doi: 10.3109/00952990.2013.798663. Epub 2013 Jun 28.
Other Identifiers
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