Proposal Evaluating Time-specific Relationships Between Variables of Pain, Stress, and Bloating in IBS Diarrhea and Constipation Symptoms Using a Palm Pilot

NCT ID: NCT00619125

Last Updated: 2017-06-20

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 85 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2008-04-30
• Study Completion Date: 2009-04-30

Brief Summary

Purpose: The associations between pain, stress, bloating, and their short interval temporal relationships to defecation in IBS D, C & M are of great interest to the field of functional GI disorders, but have not been adequately studied. Broad recall based assessments (i.e.,over past week or month) of pain and bloating have been key features of the diagnosis of IBS, however such long term retrospective recall of symptom experience has been shown to be unreliable and influenced by outside factors (heuristics, recall bias, etc.). Short interval assessment may provide a more accurate picture of patient symptom experience Participants: Patients with IBS in general and IBS subtypes (IBS-C, D, M) Procedures (methods): Study participants could be asked to record data at randomly assigned points throughout the day, as well as during the course of a diarrheal or constipated stool (i.e., prior to and right after a bowel movement).

Conditions

IBS, Diarrhea Predominant; IBS, Constipation Predominant; IBS, Mixed Symptoms

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

A

20 patients with IBS C

palm pilot recording responses to questionnaires

Intervention Type: OTHER

Short interval assessment (provided by data from palm pilot) may provide a more accurate picture of patient symptom experience.

D

20 Subjects without IBS

No interventions assigned to this group

B

20 patients with IBS D

palm pilot recording responses to questionnaires

Intervention Type: OTHER

Short interval assessment (provided by data from palm pilot) may provide a more accurate picture of patient symptom experience.

C

20 patients with IBS M

palm pilot recording responses to questionnaires

Intervention Type: OTHER

Short interval assessment (provided by data from palm pilot) may provide a more accurate picture of patient symptom experience.

Interventions

palm pilot recording responses to questionnaires

Short interval assessment (provided by data from palm pilot) may provide a more accurate picture of patient symptom experience.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

1. The subject signs and dates a written informed consent form (ICF) prior to any study-related activities, including discontinuation of any prohibited medications.

2. The subject has been diagnosed with either IBS-C, IBS-D, IBS-M, or has no history of gastrointestinal symptoms (control group).

3. The subject has at least 3 pain episodes a week and does not have constant, unremitting abdominal pain.

4. The subject is at least 18 years of age and less than 75 years of age at the time of the screening visit.

5. The subject is fluent in English.

6. The subject is an ambulatory outpatient. Ambulatory is defined as not depending exclusively on a wheelchair for mobility. Nursing home subjects may be enrolled provided they are ambulatory. Subjects with spinal cord injuries resulting in paraplegia may not be enrolled.

Exclusion Criteria

1. The subject exhibits evidence of a biochemical or structural abnormality of the digestive tract. These conditions include (but are not limited to) the following:

• Inflammatory bowel disease (Crohn's disease or ulcerative colitis),
• GI surgery (with the exceptions of appendectomy; cholecystectomy; benign polypectomy; fundoplication without gas bloat syndrome, 6 months post-surgery; herniorrhaphy without bowel resection, 1 month post-surgery; hemorrhoidectomy, at least 2 months post-surgery; and hiatal hernia repair),
• GI malignancy, GI obstruction

2. In the opinion of the investigator the subject has a concurrent illness or disability (excluding IBS) that may affect the interpretation of clinical efficacy and/or safety data or otherwise contraindicates participation in this clinical study (e.g., an unstable cardiovascular, renal, hepatic, pulmonary, endocrine, metabolic, GI, hematological, or neurological condition).

3. The subject has been diagnosed with a major psychiatric disorder within the past 2 years that required hospitalization and/or involved an attempted suicide (e.g., major depression or psychoses). Subjects diagnosed with a major psychiatric disorder that did not require hospitalization or involve an attempted suicide must have remained on a stable dose of medication for at least 6 months prior to the screening visit.

4. The subject has a history of alcohol or substance abuse within the past 2 years.

5. The subject has any evidence or treatment of malignancy (other than localized basal cell, squamous cell skin cancer or cancer in situ that has been resected) within the previous 5 years.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Takeda Pharmaceuticals North America, Inc.

INDUSTRY

Sponsor Role: collaborator

University of North Carolina, Chapel Hill

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Douglas Drossman, MD

Role: PRINCIPAL_INVESTIGATOR

UNC-Chapel Hill

Other Identifiers

07-1782

Identifier Type: -

Identifier Source: org_study_id