Inheritance of Osteosarcoma & Paget's Disease Through Chromosome 18:

NCT ID: NCT00615628

Last Updated: 2013-05-30

Basic Information

• Recruitment Status: TERMINATED
• Total Enrollment: 8 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2002-04-30
• Study Completion Date: 2009-12-31

Brief Summary

Researchers have previously demonstrated loss of heterozygosity in a region on chromosome 18q, associated with osteogenic sarcomas in bone affected by Paget's disease. The loci used in this study are specifically described by those authors as showing loss of heterozygosity in 6 of 7 affected families.

Detailed Description

As above, no additional information

Conditions

Osteosarcoma; Paget's Disease

Study Design

• Observational Model Type: FAMILY_BASED
• Study Time Perspective: PROSPECTIVE

Study Groups

family members

family members of the proband and father identified

No interventions assigned to this group

Eligibility Criteria

Exclusion Criteria

• The subjects are proband and father along with unaffected blood relatives. Their peripheral blood will act as a control and provide information to delineate the inheritance from the father, as seen in the son.

• Not part of the family

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

State University of New York - Upstate Medical University

OTHER

Sponsor Role: lead

Responsible Party

Timothy Damron, M.D.

Associate Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Timothy A Damron, MD

Role: PRINCIPAL_INVESTIGATOR

State University of New York - Upstate Medical University

Locations

SUNY Upstate Medical University

Syracuse, New York, United States

Countries

United States

Other Identifiers

IRB #4168

Identifier Type: OTHER

Identifier Source: secondary_id

Osteosarcoma & Paget's Disease

Identifier Type: -

Identifier Source: org_study_id