Clinical Trial to Evaluate the Efficacy and Safety of Fesoterodine in Comparison to Tolterodine Extended Release(ER)in Patients With Overactive Bladder.

NCT ID: NCT00611026

Last Updated: 2011-02-02

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

2417 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-02-29

Study Completion Date

2009-10-31

Brief Summary

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To evaluate the efficacy and safety of fesoterodine in comparison to tolterodine and placebo for overactive bladder

Detailed Description

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Conditions

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Overactive Bladder

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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1

Group Type ACTIVE_COMPARATOR

Tolterodine ER

Intervention Type DRUG

The tolterodine treatment will be 4 mg once daily(QD) for 12 weeks.

2

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Placebo treatment will be once daily(QD) for 12 weeks.

3

Group Type EXPERIMENTAL

Fesoterodine

Intervention Type DRUG

The fesoterodine treatment will start with 4 mg once daily(QD) for 1 week followed by a forced dose-escalation to 8mg once daily(QD) for 11 weeks.

Interventions

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Tolterodine ER

The tolterodine treatment will be 4 mg once daily(QD) for 12 weeks.

Intervention Type DRUG

Placebo

Placebo treatment will be once daily(QD) for 12 weeks.

Intervention Type DRUG

Fesoterodine

The fesoterodine treatment will start with 4 mg once daily(QD) for 1 week followed by a forced dose-escalation to 8mg once daily(QD) for 11 weeks.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Adult subjects with overactive bladder symptoms (subject-reported) for greater than or equal to 3 months prior to Screening/Enrollment visit.
* Reported at least an average of 1 UUI episode per 24 hours in the 3-day bladder diary prior to the Randomization/Baseline visit
* Mean urinary frequency of greater than or equal to 8 micturitions per 24 hours as verified by the 3-day bladder diary prior to randomization/Baseline visit.

Exclusion Criteria

* Subjects with any condition that would contraindicate their usage of fesoterodine including: hypersensitivity to the active substance (fesoterodine fumarate) or to peanut or soya or any of the excipients, urinary retention, gastric retention, uncontrolled narrow angle glaucoma, myasthenia gravis, severe hepatic impairment (Child Pugh C), severe ulcerative colitis, and toxic megacolon.
* Subjects with clinically significant hepatic or renal disease or other significant unstable diseases.
* OAB symptoms caused by neurological conditions, known pathologies of urinary tract, etc.
* Subjects with previous history of acute urinary retention requiring catheterization, or severe voiding difficulties in the judgment of the investigator, prior to baseline.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pfizer

INDUSTRY

Sponsor Role lead

Responsible Party

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Pfizer Inc

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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Enterprise, Alabama, United States

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Mobile, Alabama, United States

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Montgomery, Alabama, United States

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Chandler, Arizona, United States

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Peoria, Arizona, United States

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Tucson, Arizona, United States

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Little Rock, Arkansas, United States

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Anaheim, California, United States

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Clovis, California, United States

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Fresno, California, United States

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Fresno, California, United States

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San Diego, California, United States

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Torrance, California, United States

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Upland, California, United States

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Vista, California, United States

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Westlake Village, California, United States

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Englewood, Colorado, United States

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New London, Connecticut, United States

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Bonita Spring, Florida, United States

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Hollywood, Florida, United States

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Jacksonville, Florida, United States

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Jacksonville, Florida, United States

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Lake Worth, Florida, United States

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Leesburg, Florida, United States

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Longwood, Florida, United States

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Loxahatchee Groves, Florida, United States

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Miami, Florida, United States

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Miami, Florida, United States

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Naples, Florida, United States

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Pembroke Pines, Florida, United States

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Stuart, Florida, United States

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Tallahassee, Florida, United States

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West Palm Beach, Florida, United States

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Atlanta, Georgia, United States

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Atlanta, Georgia, United States

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Meridian, Idaho, United States

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Chicago, Illinois, United States

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Peoria, Illinois, United States

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Avon, Indiana, United States

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Evansville, Indiana, United States

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Noblesville, Indiana, United States

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Overland Park, Kansas, United States

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Overland Park, Kansas, United States

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Lexington, Kentucky, United States

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Lexington, Kentucky, United States

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Louisville, Kentucky, United States

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Louisville, Kentucky, United States

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Metairie, Louisiana, United States

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Baltimore, Maryland, United States

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Bel Air, Maryland, United States

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North Dartmouth, Massachusetts, United States

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Ann Arbor, Michigan, United States

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Royal Oak, Michigan, United States

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Troy, Michigan, United States

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Edina, Minnesota, United States

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Sartell, Minnesota, United States

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Olive Branch, Mississippi, United States

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Picayune, Mississippi, United States

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Kansas City, Missouri, United States

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St Louis, Missouri, United States

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Lincoln, Nebraska, United States

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Lincoln, Nebraska, United States

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Omaha, Nebraska, United States

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Las Vegas, Nevada, United States

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Hamilton, New Jersey, United States

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Williamsville, New York, United States

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Cary, North Carolina, United States

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Raleigh, North Carolina, United States

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Raleigh, North Carolina, United States

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Winston-Salem, North Carolina, United States

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Cincinnati, Ohio, United States

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Cincinnati, Ohio, United States

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Bensalem, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Pittsburgh, Pennsylvania, United States

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Uniontown, Pennsylvania, United States

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Cumberland, Rhode Island, United States

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Pawtucket, Rhode Island, United States

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Anderson, South Carolina, United States

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Greer, South Carolina, United States

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Summerville, South Carolina, United States

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Johnson City, Tennessee, United States

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Nashville, Tennessee, United States

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New Tazewell, Tennessee, United States

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Beaumont, Texas, United States

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Beaumont, Texas, United States

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Bryan, Texas, United States

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Plano, Texas, United States

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Plano, Texas, United States

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San Antonio, Texas, United States

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Sugar Land, Texas, United States

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Midvale, Utah, United States

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West Jordan, Utah, United States

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Arlington, Virginia, United States

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Charlottesville, Virginia, United States

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Richmond, Virginia, United States

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Virginia Beach, Virginia, United States

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Virginia Beach, Virginia, United States

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Weber City, Virginia, United States

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Seattle, Washington, United States

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Seattle, Washington, United States

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Spokane, Washington, United States

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Salvador, Estado de Bahia, Brazil

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Goiânia, Goiás, Brazil

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Curitiba, Paraná, Brazil

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Rio de Janeiro, Rio de Janeiro, Brazil

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Porto Alegre, Rio Grande do Sul, Brazil

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São Paulo, São Paulo, Brazil

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Pernik, , Bulgaria

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Pleven, , Bulgaria

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Plovdiv, , Bulgaria

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Plovdiv, , Bulgaria

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Sofia, , Bulgaria

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Veliko Tarnovo, , Bulgaria

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Surrey, British Columbia, Canada

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Winnipeg, Manitoba, Canada

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Halifax, Nova Scotia, Canada

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Oshawa, Ontario, Canada

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Chicoutimi, Quebec, Canada

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Montreal, Quebec, Canada

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Montreal, Quebec, Canada

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Montreal, Quebec, Canada

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Trois-Rivières, Quebec, Canada

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Saskatoon, Saskatchewan, Canada

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Barranquilla, Atlántico, Colombia

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Bogotá, Colombia, Colombia

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Alajuela, Alajuela Province, Costa Rica

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Cartago, Cartago Province, Costa Rica

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San José, Provincia de San José, Costa Rica

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Tallinn, , Estonia

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Tallinn, , Estonia

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Tartu, , Estonia

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Berlin, , Germany

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Berlin, , Germany

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Grünstadt, , Germany

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Hamburg, , Germany

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Krumbach, , Germany

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Leipzig, , Germany

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Marburg, , Germany

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Muelheim A.d. Ruhr, , Germany

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München, , Germany

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München, , Germany

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Heraklion/Voutes, Crete, Greece

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Alexandroupoli, , Greece

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Athens, Maroussi, , Greece

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Larissa, , Greece

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Thessaloniki, , Greece

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Debrecen, , Hungary

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Győr, , Hungary

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Nyíregyháza, , Hungary

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Salgótarján, , Hungary

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Szentes, , Hungary

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Hyderabad, Andhra Pradesh, India

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Ahmedabad, Gujarat, India

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Nadiād, Gujarat, India

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Bengaluru, Karnataka, India

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Pune, Maharashtra, India

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New Delhi, , India

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Beaumont, Dublin, Ireland

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Dublin, , Ireland

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Riga, , Latvia

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Kaunas, , Lithuania

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Kaunas, , Lithuania

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Klaipėda, , Lithuania

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Vilnius, , Lithuania

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Vilnius, , Lithuania

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Kuala Lumpur, , Malaysia

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Kuala Lumpur, , Malaysia

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Bialystok, , Poland

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Bydgoszcz, , Poland

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Gdynia, , Poland

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Krakow, , Poland

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Lublin, , Poland

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Poznan, , Poland

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Słupsk, , Poland

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Bucharest, București, Romania

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Bucharest, Sector 5,, Romania

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Sibiu, Sibiu County, Romania

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Arad, , Romania

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Moscow, , Russia

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Moscow, , Russia

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Moscow, , Russia

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Moscow, , Russia

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Moscow, , Russia

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Moscow, , Russia

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Rostov-on-Don, , Russia

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Saint Petersburg, , Russia

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Saint Petersburg, , Russia

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Saint Petersburg, , Russia

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Saint Petersburg, , Russia

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Singapore, Singapore, Singapore

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Nitra, , Slovakia

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Považská Bystrica, , Slovakia

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Prešov, , Slovakia

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Trenčín, , Slovakia

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Zvolen, , Slovakia

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Claremont, Cape Town, South Africa

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Bloemfontein, Free State, South Africa

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Vosloorus, Gauteng, South Africa

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Durban, KwaZulu-Natal, South Africa

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Durban, KwaZulu-Natal, South Africa

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Pietermaritzburg, KwaZulu-Natal, South Africa

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Pretoria, , South Africa

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Roodepoort, , South Africa

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Jeonju, Jeollabuk-do, South Korea

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Busan, , South Korea

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Daegu, , South Korea

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Incheon, , South Korea

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Seoul, , South Korea

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Suwon, , South Korea

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Santander, Cantabria, Spain

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Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain

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Madrid, Madrid, Spain

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San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain

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Valencia, Valencia, Spain

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Valencia, Valencia, Spain

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Karlskoga, , Sweden

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Malmo, , Sweden

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Norrköping, , Sweden

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Örebro, , Sweden

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Skövde, , Sweden

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Stockholm, , Sweden

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Chernivtsi, , Ukraine

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Dnipropetrovsk, , Ukraine

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Kyiv, , Ukraine

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Uzhhorod, , Ukraine

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Zaporizhzhia, , Ukraine

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Countries

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United States Brazil Bulgaria Canada Colombia Costa Rica Estonia Germany Greece Hungary India Ireland Latvia Lithuania Malaysia Poland Romania Russia Singapore Slovakia South Africa South Korea Spain Sweden Ukraine

References

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Stoniute A, Madhuvrata P, Still M, Barron-Millar E, Nabi G, Omar MI. Oral anticholinergic drugs versus placebo or no treatment for managing overactive bladder syndrome in adults. Cochrane Database Syst Rev. 2023 May 9;5(5):CD003781. doi: 10.1002/14651858.CD003781.pub3.

Reference Type DERIVED
PMID: 37160401 (View on PubMed)

Wagg AS, Herschorn S, Carlsson M, Fernet M, Oelke M. A plain language summary of the likelihood of symptom relief for patients taking fesoterodine for overactive bladder. J Comp Eff Res. 2022 Sep;11(13):919-925. doi: 10.2217/cer-2022-0041. Epub 2022 Jul 26.

Reference Type DERIVED
PMID: 35881009 (View on PubMed)

Related Links

Other Identifiers

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A0221046

Identifier Type: -

Identifier Source: org_study_id

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