Open-label Long-term Extension Study of Fesoterodine in Japanese Subjects With Neurogenic Detrusor Overactivity.

NCT ID: NCT02501928

Last Updated: 2020-11-30

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-06-05

Study Completion Date

2020-04-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to investigate the safety and tolerability of fesoterodine following once daily long-term treatment in Japanese pediatric neurogenic detrusor overactivity (NDO) subjects.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This is a Phase 3, multi-center, open-label long-term extension study in Japanese NDO subjects who participated and completed in the precedent Study A0221047 which is a 24 weeks, randomized, open label study, to investigate the safety and tolerability of fesoterodine.

This study consists of a 28-week open-label treatment period followed by a 4-week follow-up. In addition, subjects in the oxybutynin arm of the precedent Study A0221047 will continue the fesoterodine treatment until Week 40 visit in this study, in order to obtain fesoterodine 1 year treatment data.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Urinary Bladder, Neurogenic

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

neurogenic detrusor overactivity fesoterodine Japan

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NON_RANDOMIZED

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Fesoterodine PR 4 mg

Fesoterodine PR 4 mg for 28 or 40 weeks in open-label treatment period

Group Type EXPERIMENTAL

Fesoterodine PR 4 mg

Intervention Type DRUG

Fesoterodine 4 mg tablet once daily for 28 or 40 weeks

Fesoterodine PR 8 mg

Fesoterodine PR 8 mg for 28 or 40 weeks in open-label treatment period

Group Type EXPERIMENTAL

Fesoterodine PR 8 mg

Intervention Type DRUG

Fesoterodine PR 8 mg tablet once daily for 28 or 40 weeks

Fesoterodine BIC 2 mg

Fesoterodine BIC 2 mg for 28 weeks in open-label treatment period

Group Type EXPERIMENTAL

Fesoterodine BIC 2 mg

Intervention Type DRUG

Fesoterodine BIC 2 mg tablet once daily for 28 weeks

Fesoterodine BIC 4 mg

Fesoterodine BIC 4 mg for 28 weeks in open-label treatment period

Group Type EXPERIMENTAL

Fesoterodine BIC 4 mg

Intervention Type DRUG

Fesoterodine BIC 4 mg tablet once daily for 28 weeks

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Fesoterodine PR 4 mg

Fesoterodine 4 mg tablet once daily for 28 or 40 weeks

Intervention Type DRUG

Fesoterodine PR 8 mg

Fesoterodine PR 8 mg tablet once daily for 28 or 40 weeks

Intervention Type DRUG

Fesoterodine BIC 2 mg

Fesoterodine BIC 2 mg tablet once daily for 28 weeks

Intervention Type DRUG

Fesoterodine BIC 4 mg

Fesoterodine BIC 4 mg tablet once daily for 28 weeks

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

•Subjects who completed 24 week treatment and all visit procedures in the precedent Study A0221047

Exclusion Criteria

* Subjects who had major protocol violation (as determined by the Sponsor) in Study A0221047
* Concomitant medications which may increase the risk to subjects or confound study results
* Other medical conditions which may increase the risk to subjects or confound study results
Minimum Eligible Age

6 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Pfizer

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Aichi Children's Health and Medical Center

Ōbu, Aichi-ken, Japan

Site Status

Chiba Children's Hospital

Midori-ku Chiba-shi, Chiba, Japan

Site Status

Fukuoka Children's Hospital

Fukuoka, Fukuoka, Japan

Site Status

Kanagawa Children's Medical Center

Yokohama, Kanagawa, Japan

Site Status

Osaka Women's and Children's Hospital

Izumi-shi, Osaka, Japan

Site Status

Shizuoka Children's Hospital

Aoi-ku Shizuoka-shi, Shizuoka, Japan

Site Status

Dokkyo Medical University Hospital

Shimotsuga-gun, Tochigi, Japan

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Japan

Provided Documents

Download supplemental materials such as informed consent forms, study protocols, or participant manuals.

Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

A0221109

Identifier Type: -

Identifier Source: org_study_id