A Feasibility Study of Adaptive Intensity-Modulated Radiation Therapy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

TERMINATED

Clinical Phase

EARLY_PHASE1

Total Enrollment

5 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-01-31

Study Completion Date

2008-01-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Patients with head and neck cancer and are schedule to receive standard radiation therapy known as IMRT to treat cancer

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Intensity-Modulated Radiotherapy for Recurrent Head and Neck Cancer

NCT00257335

Carcinoma of the Head and Neck

WITHDRAWN PHASE2

Fractionated Radiation Therapy in Treating Advanced Squamous Cell Carcinoma of the Head and Neck

NCT00771641

Head and Neck Cancer

COMPLETED PHASE3

A Feasibility Study On Continuous Adaptive [18f]Fdg-Pet-Guided Radiotherapy For Head and Neck Cancer

NCT01208883

Squamous Cell Carcinoma

COMPLETED PHASE1

SBRT + Immunomodulating Systemic Therapy for Inoperable, Recurrent H&N

NCT03402737

Head and Neck Neoplasm

TERMINATED NA

Intensity Modulated Radiotherapy in Recurrent T1-2 Nasopharyngeal Carcinoma

NCT02113423

Nasopharyngeal Cancer Recurrent

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

In this study, we will plan additional measurements of the position of the patient's organs weekly during radiation treatment. We will analyze these measurements in order to evaluate whether we need to adjust our treatment procedures for the remainder of the treatments. We might adjust the dose of radiation received to specific organs in order to try to minimize the amount of radiation the healthy tissue receives.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Head and Neck Cancer

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

IMRT

External beam radiation with 6 MV photons will be delivered in 200 cGy daily fractions, 35 fractions over 7 weeks for a total dose of 7000 cGy.

Group Type EXPERIMENTAL

IMRT

Intervention Type RADIATION

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

IMRT

Intervention Type RADIATION

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Age \>= 18
* Karnofsky Performance Status of \>= 60
* New diagnosis of head-and-neck cancer, all subsites included (i.e. nasopharynx, oropharynx, oral cavity, hypopharynx, larynx.)
* All stages with measurable gross disease (\>= 1.0 cm) by CT imaging
* Pathologic confirmation of squamous cell carcinoma by biopsy or cytology
* Signed study-specific consent form
* Sequential or concurrent chemotherapy is allowed but not mandated. (no chemotherapy is allowed if patient is judged not to be a candidate for chemotherapy by the medical oncologist)

Exclusion Criteria

* Age \< 18
* Karnofsky Performance Status \< 60
* Radiographic or pathologic evidence of distant metastatic disease (i.e. other than cervical lymph nodes)
* Prior radiation therapy to the head-and-neck region

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No