Study of Soft Contact Lens Use With 7 Day Extended Wear

NCT ID: NCT00597467

Last Updated: 2020-07-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

460 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-03-31

Study Completion Date

2007-11-30

Brief Summary

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To compare the safety and efficacy of the CVI silicone-hydrogel lens worn on an extended wear basis for a period of up to 7 days and 6 nights with the Acuvue 2 soft contact lenses.

Detailed Description

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To compare the safety and efficacy of the CVI silicone-hydrogel lens worn on an extended wear basis for a period of up to 7 days and 6 nights with the Acuvue 2 soft contact lenses in this open-labeled randomized study.

Conditions

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Ametropia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Test Contact Lenses

VISA (comfilcon A) Silicone Hydrogel Soft contact lens

Group Type EXPERIMENTAL

VISA (comfilcon A) Silicone Hydrogel Soft contact lens

Intervention Type DEVICE

Test device

Control Contact Lenses

Acuvue 2 Soft Contact Lens

Group Type ACTIVE_COMPARATOR

Acuvue 2 Soft Contact Lens

Intervention Type DEVICE

Control device

Interventions

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VISA (comfilcon A) Silicone Hydrogel Soft contact lens

Test device

Intervention Type DEVICE

Acuvue 2 Soft Contact Lens

Control device

Intervention Type DEVICE

Other Intervention Names

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Biofinity (comfilcon A)

Eligibility Criteria

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Inclusion Criteria

1. Be at least 18 years of age as of the date of evaluation.
2. Require lens powers between -0.50 and -6.00 diopters sphere with no more than 1.00 diopter of refractive astigmatism and be willing to wear lenses in both eyes.
3. Be correctable to visual acuities of at least 20/25 in each eye with spectacles.
4. Be in good general health, based on his/her knowledge.
5. Be able and willing to adhere to the instructions set forth in this protocol and able to keep all specified appointments.
6. Possess wearable and visually functional eyeglasses.

Exclusion Criteria

1. Previously unsuccessful with contact lens wear.
2. Rigid gas permeable contact lens wear within the past 12 months.
3. Previous refractive surgery; current or previous orthokeratology treatment.
4. Subject is wearing lenses in a modified monovision modality (multifocal lens in one eye). NOTE: subjects may not wear monovision lenses at any time during the study unless they are wearing spherical monovision lenses prior to enrollment.
5. Aphakia, keratoconus or an irregular cornea.
6. A known history of corneal hypoesthesia
7. Clinically significant (grade 3 or 4) anterior segment abnormalities or any infection of the eye, lids, or associated structures.
8. Ocular or systemic disease or need for medication which might interfere with contact lens wear. i.e., Sjögren's syndrome, type II diabetes, etc.
9. Slit lamp findings that would contraindicate contact lens wear, including but not limited to:

* History of corneal ulcer, corneal infiltrates or fungal infections.
* Pterygium, pinguecula or corneal scars within the visual axis
* Pathological dry eye or associated findings (examples: Sjögren's syndrome, lupus erythematosus, sclerodermia)
* Neovascularization or ghost vessels \> 1mm in from the limbus
* Seborrheic eczema, seborrheic conjunctivitis
* History of papillary conjunctivitis greater than Grade 2 (Mild)
* Anterior uveitis or iritis (past or present)
10. Known sensitivity to the care systems used in this study.
11. Poor personal hygiene
12. Current pregnancy or is lactating (to the best of the subject's knowledge) or subject is planning pregnancy within the next 13 months.
13. Any active participation in another clinical study within 30 days prior to this study.
14. Subject is a member, relative or household member of the office staff, including the investigator(s).

Subjects must read, indicate understanding of, and sign the Informed Consent Form.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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CooperVision, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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William Gleason, OD

Role: STUDY_DIRECTOR

FRS

Locations

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La Mesa Vision Care Center

La Mesa, California, United States

Site Status

(Private Practice)

San Diego, California, United States

Site Status

Drs. Cook, Reeder and Associates

San Diego, California, United States

Site Status

(Private Practice)

Santa Monica, California, United States

Site Status

Eye Care Associates, P.C.

Fort Collins, Colorado, United States

Site Status

Eola Eyes

Orlando, Florida, United States

Site Status

(Private Practice)

Honolulu, Hawaii, United States

Site Status

Kato & Shoji Optometrists

Honolulu, Hawaii, United States

Site Status

Eye Care Associates of Hawaii

Waipahu, Hawaii, United States

Site Status

Davis Eyecare Associates

Oak Lawn, Illinois, United States

Site Status

(Private Practice)

Andover, Massachusetts, United States

Site Status

Vision Care Associates

East Lansing, Michigan, United States

Site Status

The Koetting Associates Inc.

St Louis, Missouri, United States

Site Status

Concord Ophthalmological Associates

Concord, New Hampshire, United States

Site Status

Place Optical Company Inc

Le Roy, New York, United States

Site Status

Quinn Quinn & Associates

Athens, Ohio, United States

Site Status

Western Reserve Vision Care

Beachwood, Ohio, United States

Site Status

Ohio State University

Columbus, Ohio, United States

Site Status

Professional Eye Care Associates

Columbus, Ohio, United States

Site Status

Primary Eyecare Group, P.C.

Brentwood, Tennessee, United States

Site Status

(Private Practice)

Salt Lake City, Utah, United States

Site Status

Twin Lakes Vision

Federal Way, Washington, United States

Site Status

Snowy Range Vision Center

Laramie, Wyoming, United States

Site Status

Countries

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United States

Other Identifiers

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CVI060105

Identifier Type: -

Identifier Source: org_study_id

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