Jarvik 2000 Heart as a Bridge to Cardiac Transplantation - Pivotal Trial

NCT ID: NCT00591799

Last Updated: 2013-09-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2/PHASE3

Total Enrollment

150 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-04-30

Study Completion Date

2012-05-31

Brief Summary

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The purpose of the study is to determine the safety and effectiveness of the Jarvik 2000 Heart as a bridge to heart transplantation in end-stage heart failure patients who are approved heart transplant candidates.

Detailed Description

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The Jarvik 2000 Heart is a silent compact axial flow impeller pump of 1 inch diameter, weighing 90g with a displacement volume of 25ml. The pump is implanted into the apex of the left ventricle by left thoracotomy, or by mid-sternotomy, or by the subcostal approach. A vascular graft offloads to either the descending thoracic aorta, the ascending thoracic aorta, or the abdominal aorta. The impeller rotates at speeds of 8,000 to 12,000 rpm providing blood flow of up to seven L/minute. At higher speeds the pump can produce 10 L/minute. Power is provided through an abdominal drive line.

Conditions

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Heart Failure

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Jarvik 2000 Ventricular Assist System

Jarvik 2000 Ventricular Assist System

Group Type EXPERIMENTAL

The Jarvik 2000 Ventricular Assist System

Intervention Type DEVICE

Jarvik 2000 Heart implantation is intended for patient's with end-stage heart failure who are approved heart transplant candidates - who meet all of the study's inclusion criteria and none of its exclusion criteria.

Interventions

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The Jarvik 2000 Ventricular Assist System

Jarvik 2000 Heart implantation is intended for patient's with end-stage heart failure who are approved heart transplant candidates - who meet all of the study's inclusion criteria and none of its exclusion criteria.

Intervention Type DEVICE

Other Intervention Names

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Jarvik 2000

Eligibility Criteria

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Inclusion Criteria

* Transplant listed UNOS status IA or IB patients.
* BSA \>1.5 m2 and \<2.3 m2.
* Dependent on one or more intravenous inotropic agents or an intraaortic balloon pump (IABP).

Exclusion Criteria

* Known risk factors or conditions that would contraindicate LVAD implantation or adversely affect patient survival.
* Evidence of end organ dysfunction.
* Known coagulopathy or contraindication of anticoagulation or antiplatelet agents.
* Systemic infection.
* Malignancies not in remission.
* Current participation in investigational trials with other devices, drugs, or biologic agents.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Jarvik Heart, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Robert Jarvik, MD

Role: STUDY_CHAIR

Jarvik Heart, Inc. SPONSOR

Locations

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University of Maryland Medical Center

Baltimore, Maryland, United States

Site Status

Countries

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United States

References

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Selzman CH, Feller ED, Walker JC, Sheridan BC, Silvestry SC, Daly RC, Anyanwu AC, Madigan D, Liu PY, Frazier OH, Jorde UP, Griffith BP. The Jarvik 2000 Left Ventricular Assist Device: Results of the United States Bridge to Transplant Trial. ASAIO J. 2023 Feb 1;69(2):174-182. doi: 10.1097/MAT.0000000000001750. Epub 2022 Apr 13.

Reference Type DERIVED
PMID: 35421002 (View on PubMed)

Other Identifiers

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G000058

Identifier Type: -

Identifier Source: org_study_id