Reliability of a Top Mount Actuation Indicator With Levalbuterol MDI in Adult and Pediatric Subjects With Asthma or COPD

NCT ID: NCT00583986

Last Updated: 2012-02-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

150 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-09-30

Study Completion Date

2006-03-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This is a study to investigate the reliability, ruggedness and safety of the top mounted actuation indicator (TMAI) when used with Levalbuterol HFA MDI.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This is an open-label, multicenter, TMAI study with Levalbuterol HFA MDI in adult and pediatric subjects with asthma or COPD. Period I: One week, open-label, run-in period during which subjects must have asthma or COPD symptoms requiring use of, as needed, Levalbuterol HFA MDI(without TMAI) on at least half of the days \[4-12 actuations on a single day\]. Period II: Nine week, open-label period during which subjects will use the Levalbuterol HFA MDI with TMAI PRN. The total study duration for a subject will not exceed 10 weeks. This study was previously posted by Sepracor Inc. In October 2009, Sepracor Inc. was acquired by Dainippon Sumitomo Pharma., and in October 2010, Sepracor Inc's name was changed to Sunovion Pharmaceuticals Inc.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Asthma Chronic Obstructive Pulmonary Disease COPD

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

1

Levalbuterol HFA MDI with top mounted actuation indicator

Group Type EXPERIMENTAL

Levalbuterol HFA MDI with top mounted actuation indicator

Intervention Type DRUG

Levalbuterol HFA MDA with top mounted actuation indicator

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Levalbuterol HFA MDI with top mounted actuation indicator

Levalbuterol HFA MDA with top mounted actuation indicator

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Xopenex HFA®

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Subject must have a documented diagnosis of asthma or COPD for a minimum of 6 months.
* Subject must have stable baseline asthma or COPD and have been using a beta-adrenergic agonist, and/or anti-asthma anti-inflammatory medication, and/or over-the-counter asthma medication for at least 6 months.
* Subject must be in good health with the exception of their reversible airways disease and not suffering from any chronic condition that might affect their respiratory function.

Exclusion Criteria

* Female subject who is pregnant or lactating.
* Subject who has a history of hospitalization for asthma or COPD within 45 days.
* Subject with currently diagnosed life-threatening asthma or COPD, defined as a history of asthma or COPD episodes requiring intubation, associated with hypercapnia, respiratory arrest, or hypoxic seizures within 3 months prior.
* Subject with supplemental oxygen use
* Subject with a history of cancer
* Subject with hyperthyroidism, diabetes, hypertension, cardiac diseases, or seizure disorders that currently are not well controlled by medication.
* Subject with asthma with a greater than 10-pack per year history of cigarette smoking or use of any tobacco products within 6 months.
Minimum Eligible Age

4 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Sumitomo Pharma America, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

John Hanrahan, M.D.

Role: STUDY_CHAIR

Sumitomo Pharma America, Inc.

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Encinatas, California, United States

Site Status

Huntington Beach, California, United States

Site Status

Mesa, California, United States

Site Status

Orange County, California, United States

Site Status

Riverside, California, United States

Site Status

San Diego, California, United States

Site Status

San Jose, California, United States

Site Status

Viejo, California, United States

Site Status

Walnut Creek, California, United States

Site Status

Tamarac, Florida, United States

Site Status

Russells Mills, Massachusetts, United States

Site Status

Commack, New York, United States

Site Status

Rochester, New York, United States

Site Status

Elizabeth City, North Carolina, United States

Site Status

Oklahoma City, Oklahoma, United States

Site Status

Medford, Oregon, United States

Site Status

Portland, Oregon, United States

Site Status

Philadelphia, Pennsylvania, United States

Site Status

Simpsonville, South Carolina, United States

Site Status

Chattanooga, Tennessee, United States

Site Status

Austin, Texas, United States

Site Status

Braunfels, Texas, United States

Site Status

San Antonio, Texas, United States

Site Status

Burke, Virginia, United States

Site Status

Richmond, Virginia, United States

Site Status

Morgantown, West Virginia, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

Related Links

Access external resources that provide additional context or updates about the study.

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

051-357

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.