Bio-Seal Biopsy Track Plug for Reducing Pneumothorax Rates Post Lung Biopsy Procedure

NCT ID: NCT00562302

Last Updated: 2013-03-27

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

339 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-04-30

Study Completion Date

2008-08-31

Brief Summary

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BS-1053 A Prospective Randomized Multi-Centered Safety and Efficacy Evaluation of the Bio-Seal Biopsy Track Plug for Reducing Pneumothorax Rates Post Lung Biopsy Procedures

Detailed Description

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This is a multi-centered, randomized trial in patients receiving lung biopsies. Patients will be randomized to either receive or not receive a Bio-Seal Biopsy Track Plug after a lung biopsy per standard hospital protocol. This study is designed to demonstrate safety and efficacy of the Bio-Seal Biopsy Track Plug in reducing pneumothorax rates post lung biopsy.

Conditions

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Pneumothorax

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Bio-Seal Group

Bio-Seal Plug Implanted

Group Type EXPERIMENTAL

Bio-Seal Plug

Intervention Type DEVICE

Deployment of the Bio-Seal plug in needle track

Control Group

Control group with no intervention

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Bio-Seal Plug

Deployment of the Bio-Seal plug in needle track

Intervention Type DEVICE

Other Intervention Names

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Bio-Seal™ Lung Biopsy Tract System

Eligibility Criteria

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Inclusion Criteria

* The patient must meet all medical conditions for lung biopsy;
* The patient must be at least 18 years of age;
* The patient, or legal representative, must understand and provide written consent for the procedure;
* The patient has a non-calcified, radiologically suspicious opacity or lung nodule, including a metastatic lung module, or mass of at least 1.0 cm in size; as determined by CT scan equipped with measurement software. Suspicious nodules observed by CT scan are defined as non-calcified masses with convex borders, not known to be stable. Suspicious nodules can also be defined as masses demonstrating opacity on chest x-ray that are suspicious by radiographic or clinical means and require biopsy.

Exclusion Criteria

* Patients with radiological findings of bullous emphysema located in the area of the anticipated biopsy and biopsy needle track;
* Patients who cannot tolerate mild sedation, possibly secondary to poor respiratory status;
* Female patients who are pregnant. Note: patients of childbearing potential must have a serum or urine pregnancy test no more than one week prior to the biopsy procedure, and be instructed not to have unprotected sexual intercourse after the test until the biopsy procedure is completed.
* Patients who are uncooperative or cannot follow instructions.
* Patients who are currently enrolled in another IDE or IND clinical investigation that has not completed the required follow-up period.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Angiotech Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Rui Avelar, MD

Role: STUDY_DIRECTOR

Angiotech Pharmaceuticals

Locations

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Scottsdale Medical Imaging

Scottsdale, Arizona, United States

Site Status

St. Josephs Radiology Limited

Tuscon, Arizona, United States

Site Status

UCLA School of Medicine

Los Angeles, California, United States

Site Status

Univerisity of California, San Diego

San Diego, California, United States

Site Status

Stanford University Medical Center

Stanford, California, United States

Site Status

Vascular and Interventional Radiology

New Haven, Connecticut, United States

Site Status

Morton Plant Mease Health Care

Clearwater, Florida, United States

Site Status

Florida Research Network

Gainesville, Florida, United States

Site Status

UMass Memorial Medical Center

Worcester, Massachusetts, United States

Site Status

St. Louis Medical Center

St Louis, Missouri, United States

Site Status

Univeristy of Cincinnati Medical Center

Cincinnati, Ohio, United States

Site Status

St Lukes Hospital

Bethlehem, Pennsylvania, United States

Site Status

Memorial Medical Center

Johnstown, Pennsylvania, United States

Site Status

Rhode Island Hospital

Providence, Rhode Island, United States

Site Status

Baptist Memorial Hospital

Memphis, Tennessee, United States

Site Status

University of Texas/MD Anderson Cancer Center

Houston, Texas, United States

Site Status

Evergreen Healthcare Diagnostic Imaging

Kirkland, Washington, United States

Site Status

Sacred Heart Medical Center & Heart Institute of Spokane

Spokane, Washington, United States

Site Status

Countries

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United States

Other Identifiers

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BS-1053

Identifier Type: -

Identifier Source: org_study_id

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