Corneal Flap Thickness Planed vs Measured After LASIK by Using Tree Different Systems Cut

NCT ID: NCT00558324

Last Updated: 2024-05-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

43 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-02-28

Study Completion Date

2007-10-31

Brief Summary

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Determine the flap thickness created by femtosecond laser or a mechanical microkeratome using in vivo confocal microscopy and compare measured versus intended flap thickness.

Detailed Description

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Eighty-six eyes had undergone LASIK were examined, al within 2 weeks to 1 month after surgery. Study involved 3 treatment groups: One with 30 eyes of 15 patients, corneal flaps were created with the microkeratome femtosecond laser 15 KHz 100μm (Intralase Corp, Irvine, Calif.), one with 30 eyes of 15 patients, corneal flaps were created with mechanical microkeratome (Hansatome 160μm (Chiron Vision Corp, Claremont, Calif) and one with 26 eyes of 13 patients, corneal flaps were created with mechanical microkeratome K3000 130μm ( BD Ophthalmic Systems, Waltham, Mass) . A central scan of the total corneal thickness was taken with the confocal microscope (Confoscan 4, Fortune Technologies, Italy) before and at 2 weeks and 1 month after surgery. Corneal epithelial thickness and the Anterior stroma morphology were analyzed by using the NAVIS software V. 3.5.0 (NIDEK, Multi-Instrument Diagnostic System, Japan).

Conditions

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Refractive Errors

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SCREENING

Blinding Strategy

NONE

Study Groups

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I

Corneal flaps were created with mechanical microkeratome (Hansatome 160μm (Chiron Vision Corp, Claremont, Calif)

Group Type EXPERIMENTAL

LASIK

Intervention Type PROCEDURE

Mechanical microkeratome Hansatome 160 microns

II

Corneal flaps were created with mechanical microkeratome K3000 130μm ( BD Ophthalmic Systems, Waltham, Mass) .

Group Type EXPERIMENTAL

LASIK

Intervention Type PROCEDURE

Mechanical microkeratome K 3000 130 microns

III

Corneal flaps were created with microkeratome femtoseconds laser (Intralase Corp, Irvine, Calif.)

Group Type EXPERIMENTAL

LASIK

Intervention Type PROCEDURE

Femtoseconds laser 100 microns

Interventions

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LASIK

Mechanical microkeratome Hansatome 160 microns

Intervention Type PROCEDURE

LASIK

Mechanical microkeratome K 3000 130 microns

Intervention Type PROCEDURE

LASIK

Femtoseconds laser 100 microns

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients ask for LASIK surgery
* Patients with stable refraction in the last year
* Patients without systemic and ocular disease
* Patients with 500 microns in pachymetry
* Normal topography

Exclusion Criteria

* Patients cannot attend their appointments
* Residual, recurrent or active ocular disease
* Previous ocular surgery except LASIK
* Autoimmune or connective tissue disease
* Pregnancy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Universidad Nacional Autonoma de Mexico

OTHER

Sponsor Role collaborator

Asociación para Evitar la Ceguera en México

OTHER

Sponsor Role lead

Principal Investigators

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Ramírez F. Manuel, MD

Role: PRINCIPAL_INVESTIGATOR

Asociación para Evitar la Ceguera

Ramírez G. Laura, MD

Role: STUDY_CHAIR

Asociación para Evitar la Ceguera

Locations

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Asociación Para Evitar la Ceguera en Mëxico, Hospital "Luis Sánchez Bulnes".

Mexico City, Mexico City, Mexico

Site Status

Countries

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Mexico

References

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Huhtala A, Pietila J, Makinen P, Suominen S, Seppanen M, Uusitalo H. Corneal flap thickness with the Moria M2 single-use head 90 microkeratome. Acta Ophthalmol Scand. 2007 Jun;85(4):401-6. doi: 10.1111/j.1600-0420.2006.00838.x.

Reference Type BACKGROUND
PMID: 17559465 (View on PubMed)

Sarayba MA, Ignacio TS, Binder PS, Tran DB. Comparative study of stromal bed quality by using mechanical, IntraLase femtosecond laser 15- and 30-kHz microkeratomes. Cornea. 2007 May;26(4):446-51. doi: 10.1097/ICO.0b013e318033e7cc.

Reference Type BACKGROUND
PMID: 17457194 (View on PubMed)

Hoffmann S, Krummenauer F, Tehrani M, Dick HB. Impact of head advance and oscillation rate on the flap parameter: a comparison of two microkeratomes. Graefes Arch Clin Exp Ophthalmol. 2003 Feb;241(2):149-53. doi: 10.1007/s00417-002-0599-z. Epub 2003 Jan 28.

Reference Type BACKGROUND
PMID: 12605270 (View on PubMed)

Belin MW, Schultze RL. Microkeratomes. Int Ophthalmol Clin. 2000 Summer;40(3):57-65. doi: 10.1097/00004397-200007000-00008. No abstract available.

Reference Type BACKGROUND
PMID: 10941646 (View on PubMed)

Eisner RA, Binder PS. Technique for measuring laser in situ keratomileusis flap thickness using the IntraLase laser. J Cataract Refract Surg. 2006 Apr;32(4):556-8. doi: 10.1016/j.jcrs.2006.01.003.

Reference Type BACKGROUND
PMID: 16698470 (View on PubMed)

Durrie DS, Kezirian GM. Femtosecond laser versus mechanical keratome flaps in wavefront-guided laser in situ keratomileusis: prospective contralateral eye study. J Cataract Refract Surg. 2005 Jan;31(1):120-6. doi: 10.1016/j.jcrs.2004.09.046.

Reference Type BACKGROUND
PMID: 15721704 (View on PubMed)

Solomon KD, Donnenfeld E, Sandoval HP, Al Sarraf O, Kasper TJ, Holzer MP, Slate EH, Vroman DT; Flap Thickness Study Group. Flap thickness accuracy: comparison of 6 microkeratome models. J Cataract Refract Surg. 2004 May;30(5):964-77. doi: 10.1016/j.jcrs.2004.01.023.

Reference Type BACKGROUND
PMID: 15130631 (View on PubMed)

Ismail MM. LASIK using the NIDEK EC-5000 for the correction of hyperopic astigmatism. J Refract Surg. 2006 Nov;22(9 Suppl):S1069-72. doi: 10.3928/1081-597X-20061102-11.

Reference Type BACKGROUND
PMID: 17444095 (View on PubMed)

Dougherty PJ. The thin-flap LASIK technique. J Refract Surg. 2005 Sep-Oct;21(5 Suppl):S650-4. doi: 10.3928/1081-597X-20050902-19.

Reference Type BACKGROUND
PMID: 16212298 (View on PubMed)

Montes-Mico R, Rodriguez-Galietero A, Alio JL. Femtosecond laser versus mechanical keratome LASIK for myopia. Ophthalmology. 2007 Jan;114(1):62-8. doi: 10.1016/j.ophtha.2006.07.019. Epub 2006 Oct 27.

Reference Type BACKGROUND
PMID: 17070593 (View on PubMed)

Ramirez M, Hernandez-Quintela E, Naranjo-Tackman R. A comparative confocal microscopy analysis after LASIK with the IntraLase femtosecond laser vs Hansatome microkeratome. J Refract Surg. 2007 Mar;23(3):305-7. doi: 10.3928/1081-597X-20070301-15.

Reference Type BACKGROUND
PMID: 17385298 (View on PubMed)

Ramirez M, Hernandez-Quintela E, Sanchez-Huerta V, Naranjo-Tackman R. Confocal microscopy of corneal flap microfolds after LASIK. J Refract Surg. 2006 Feb;22(2):155-8. doi: 10.3928/1081-597X-20060201-13.

Reference Type BACKGROUND
PMID: 16523834 (View on PubMed)

Other Identifiers

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Cornea 1

Identifier Type: -

Identifier Source: org_study_id

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