Clinical Investigation of a Femtosecond Laser for Corneal Flap Creation

NCT ID: NCT07036835

Last Updated: 2026-01-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

174 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-08-27

Study Completion Date

2026-11-30

Brief Summary

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The purpose of this study is to see how safe the WaveLight Ultraviolet Femtosecond Laser, Model 1026 (UV fs-Laser), is for creating corneal flaps during laser-assisted in situ keratomileusis (LASIK) surgery. This study will be conducted in Australia.

Detailed Description

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Subjects who qualify to participate will have both eyes treated. Each subject will be randomly assigned to 1 of 2 topical anesthetics (numbing eye drops) and each eye will be randomly assigned to either the UV fs-Laser or the WaveLight FS200 Infrared Femtosecond Laser, Model 1025 (IR fs-Laser).

Subjects will attend a total of 6 scheduled study visits, including a preoperative Screening Visit (Day -45 to -1), a Surgery Visit (Day 0), and 4 postoperative visits at Day 1, Week 1, Month 1, and Month 3/exit, for a total individual duration of participation of approximately 4 months.

Conditions

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Refractive Errors

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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UV fs-Laser/Anesthetic 1 Right, IR fs-Laser/Anesthetic 1 Left

LASIK surgery performed with the UV fs-Laser (right eye) and IR fs-Laser (left eye) as randomized with Anesthetic 1 eye drops

Group Type OTHER

LASIK Surgery

Intervention Type PROCEDURE

Laser assisted in situ keratomileusis (LASIK) surgery conducted for the purpose of correcting refractive error

UV fs-Laser

Intervention Type DEVICE

WaveLight Ultraviolet Femtosecond Laser used for creating a corneal flap during LASIK surgery

IR fs-Laser

Intervention Type DEVICE

WaveLight FS200 Infrared Femtosecond Laser used for creating a corneal flap during LASIK surgery

Anesthetic 1 eye drops

Intervention Type DEVICE

Topical anesthetic used to numb the surface of the eye

UV fs-Laser/Anesthetic 1 Left, IR fs-Laser/Anesthetic 1 Right

LASIK surgery performed with the UV fs-Laser (left eye) and IR fs-Laser (right eye) as randomized with Anesthetic 1 eye drops

Group Type OTHER

LASIK Surgery

Intervention Type PROCEDURE

Laser assisted in situ keratomileusis (LASIK) surgery conducted for the purpose of correcting refractive error

UV fs-Laser

Intervention Type DEVICE

WaveLight Ultraviolet Femtosecond Laser used for creating a corneal flap during LASIK surgery

IR fs-Laser

Intervention Type DEVICE

WaveLight FS200 Infrared Femtosecond Laser used for creating a corneal flap during LASIK surgery

Anesthetic 1 eye drops

Intervention Type DEVICE

Topical anesthetic used to numb the surface of the eye

UV fs-Laser/Anesthetic 2 Right, IR fs-Laser/Anesthetic 2 Left

LASIK surgery performed with the UV fs-Laser (right eye) and IR fs-Laser (left eye) as randomized with Anesthetic 2 eye drops

Group Type OTHER

LASIK Surgery

Intervention Type PROCEDURE

Laser assisted in situ keratomileusis (LASIK) surgery conducted for the purpose of correcting refractive error

UV fs-Laser

Intervention Type DEVICE

WaveLight Ultraviolet Femtosecond Laser used for creating a corneal flap during LASIK surgery

IR fs-Laser

Intervention Type DEVICE

WaveLight FS200 Infrared Femtosecond Laser used for creating a corneal flap during LASIK surgery

Anesthetic 2 eye drops

Intervention Type DEVICE

Topical anesthetic used to numb the surface of the eye

UV fs-Laser/Anesthetic 2 Left, IR fs-Laser/Anesthetic 2 Right

LASIK surgery performed with the UV fs-Laser (left eye) and IR fs-Laser (right eye) as randomized with Anesthetic 2 eye drops

Group Type OTHER

LASIK Surgery

Intervention Type PROCEDURE

Laser assisted in situ keratomileusis (LASIK) surgery conducted for the purpose of correcting refractive error

UV fs-Laser

Intervention Type DEVICE

WaveLight Ultraviolet Femtosecond Laser used for creating a corneal flap during LASIK surgery

IR fs-Laser

Intervention Type DEVICE

WaveLight FS200 Infrared Femtosecond Laser used for creating a corneal flap during LASIK surgery

Anesthetic 2 eye drops

Intervention Type DEVICE

Topical anesthetic used to numb the surface of the eye

Interventions

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LASIK Surgery

Laser assisted in situ keratomileusis (LASIK) surgery conducted for the purpose of correcting refractive error

Intervention Type PROCEDURE

UV fs-Laser

WaveLight Ultraviolet Femtosecond Laser used for creating a corneal flap during LASIK surgery

Intervention Type DEVICE

IR fs-Laser

WaveLight FS200 Infrared Femtosecond Laser used for creating a corneal flap during LASIK surgery

Intervention Type DEVICE

Anesthetic 1 eye drops

Topical anesthetic used to numb the surface of the eye

Intervention Type DEVICE

Anesthetic 2 eye drops

Topical anesthetic used to numb the surface of the eye

Intervention Type DEVICE

Other Intervention Names

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Model 1026 Model 1025

Eligibility Criteria

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Inclusion Criteria

* Eligible for LASIK treatment;
* Myopia as specified in the protocol;
* Uncorrected distance visual acuity of greater than or equal to 0.30 logMAR;
* Best corrected distance visual acuity of less than or equal to 0.10 logMAR;
* Presence of clear natural lens (non-cataractous eye);

Exclusion Criteria

* An active implanted device for which laser use may be a contraindication;
* Previous ocular surgery;
* Ocular conditions that may affect subject safety or impact study outcomes;
* Acute or chronic disease or illness that would increase the operative risk or confound the outcomes of the study;
* Current use of medications with known ocular side effects and photosensitivity;
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Alcon Research

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Trial Lead, Surgical

Role: STUDY_DIRECTOR

Alcon Research, LLC

Locations

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Personaleyes

Sydney, New South Wales, Australia

Site Status RECRUITING

Countries

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Australia

Central Contacts

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Alcon Call Center

Role: CONTACT

1-888-451-3937

Other Identifiers

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RFO268-C009

Identifier Type: -

Identifier Source: org_study_id

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