An Analysis of Peripheral Blood T Cell Subsets on Rheumatoid Arthritis

NCT ID: NCT00555542

Last Updated: 2008-05-09

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 10 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2006-07-31
• Study Completion Date: 2008-05-31

Brief Summary

To study the effects of T cell in peripheral blood of patients with RA undergoing selective B cell depletion have not been studied. We analyze the B and T cell subsets in patients with active RA treated undergoing this form of treatment with rituximab.

Detailed Description

• In this open labeled prospective study, we evaluate the therapeutic efficacy and peripheral blood cellular response of rituximab in 10 patients with active RA despite conventional DMARDs therapy.
• Patients are taking stable dose of methotrexate and at least 10mg folic acid per week for at least 4 weeks. Rituximab is administrated as 1000mg intravenous infusion on day 1 and day 15. Premedication as standard prescription consists of methylprednisolone 100mg IV, Chlorpheniramine maleate(piriton 10mg IV and oral paracetamol 500mg to be given 30 minutes before each infusion of rituximab. Oral prednisolone 60mg is tob e given from day 1-6 after rituximab infusion and 30mg from day 7-13.
• In patients who relapses following the first cycle can be repeated with the second cycle must fulfill the following conditions:

1. Patients must have responded clinically to the first infusion with improvement

2. Other disease modifying anti-rheumatic drugs (DMARDs) are not appropriate as determined by the investigators, either they have been on them before or are ineffective or due to side effects,

3. Patients have a disease activity score DSA>2.6

4. At least 24 weeks since the first infusion

5. Neutrophil count of >1.5 X 103/mcL

• The second infusion consists of rituximab 1000mg intravenous infusion on day 1 and day 15 as before and the same protocol of followed up every 4 weeks up to 52 weeks from the day of the first infusion.14 Premedication as standard prescription (consists of methylprednisolone 100mg IV, Chlorpheniramine maleate(piriton) 10mg IV and oral paracetamol 500mg to be given 30 minutes before each infusion of rituximab.

Conditions

Rheumatoid Arthritis

Keywords

B-cell; rituximab; Rheumatoid Arthritis

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

1

Rituximab is administrated as 1000mg intravenous infusion on day 1 and day 15.

Group Type: EXPERIMENTAL

rituximab

Intervention Type: DRUG

Patients are taking stable dose of methotrexate and at least 10mg folic acid per week for at least 4 weeks. Rituximab is administrated as 1000mg intravenous infusion on day 1 and day 15. Premedication as standard prescription consists of methylprednisolone 100mg IV, Chlorpheniramine maleate(piriton 10mg IV and oral paracetamol 500mg to be given 30 minutes before each infusion of rituximab. Oral prednisolone 60mg is tob e given from day 1-6 after rituximab infusion and 30mg from day 7-13.

Interventions

rituximab

Patients are taking stable dose of methotrexate and at least 10mg folic acid per week for at least 4 weeks. Rituximab is administrated as 1000mg intravenous infusion on day 1 and day 15. Premedication as standard prescription consists of methylprednisolone 100mg IV, Chlorpheniramine maleate(piriton 10mg IV and oral paracetamol 500mg to be given 30 minutes before each infusion of rituximab. Oral prednisolone 60mg is tob e given from day 1-6 after rituximab infusion and 30mg from day 7-13.

Intervention Type: DRUG

Other Intervention Names

Mabthera

Eligibility Criteria

Inclusion Criteria

• Age 21 or above
• Fulfilled the 1978 American college of Rheumatology(ACR) criteria for RA
• Seropositive for RF with RF>20 IU/ml
• Active disease despite treatment with at least 2 stable dose of DMARDs for at least 16 weeks, including MRX>10mg weekly
• 4 or more swollen and/or tender joints
• Stable dose of prednisolone<=12.5mg/day or NASID for at lease 4 weeks
• MTX>10mg/wk and folic acid>10 mg/wk for at lease 4 weeks

Exclusion Criteria

• Little or no ability for self-care
• Used a DMARD other than MTX(Leflunomide should be wash-out with cholestyramine 4 weeks prior screening)
• Received intra-articular,intramuscular, or intravenous corticosteroids in the last 4 weeks
• Concurrent treatment with any biologics within 8 weeks
• Infected joint prosthesis during the previous 5 years
• Autoimmune disease other than RA(except concurrent Sjogren's syndrome), active rheumatoid vasculitis, and history of systemic disease associated with arthritis, chronic fatigue syndrome.
• Serious infections, such as hepatitis, pneumonia, pyelonephritis in the previous 3 months
• Any chronic infectious disease such as renal infection, chest infection with bronchiectasis or sinusitis
• Recurrent bacterial infections with encapsulated organisms, primary or secondary immunodeficiency
• Active tuberculosis requiring treatment within the previous 3 years
• Opportunistic infection such as herpes zoster within the previous 2 months
• Any evidence of active cytomegalovirus;active Pneumocystis Jirovecl;or drug-resistant atypical mycobacterial infection
• Known hypersensitivity to murine proteins
• Current signs or symptoms of severe,progressive,or uncontrolled renal,hepatic,haematological,gastrointestinal,endocrine,pulmonary,cardias,neurological,or cerebral disease
• A history of lymphoproliferative disease including lymphoma or signs suggestive of disease,such as lymphadenopathy of unusual size or location(ie,lymphadenopathy nodes,in the posterior tangle of the neck,infraclavicular epitrochlear,or periaortic areas);splenomegaly
• Any know malignant disease except basal cell carcinoma currently or in the last 5 years

• Minimum Eligible Age: 21 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Chinese University of Hong Kong

OTHER

Sponsor Role: lead

Responsible Party

The Chinese University of Hong Kong

Principal Investigators

Edmund Kwok Ming LI, MD

Role: PRINCIPAL_INVESTIGATOR

Chinese University of Hong Kong

Locations

Department of Medicine and Therapeutics

Hong Kong, , China

Countries

China

Other Identifiers

RA-2006-005

Identifier Type: -

Identifier Source: org_study_id