Exercise,Metabolic Syndrome and Weight Regain (Echocardiography Substudy)

NCT ID: NCT00543985

Last Updated: 2017-03-01

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 36 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2007-10-31
• Study Completion Date: 2008-10-31

Brief Summary

We plan to test the hypothesis that patients with metabolic syndrome will have impaired left ventricular diastolic parameters. These parameters will be measured before and after a stress test at the end of a 3 month period of exercise training and a 10% weight loss.

Detailed Description

Patients must have 2 of the 5 criteria for metabolic syndrome and be able to exercise in a monitored setting for 45 min 5 times a week.

Conditions

Metabolic Syndrome; Obesity

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: DIAGNOSTIC
• Blinding Strategy: NONE

Study Groups

Stress Echocardiography

Echocardiography was performed prior to and within 60 seconds of completing the standard Bruce treadmill protocol.

Group Type: EXPERIMENTAL

Stress Echocardiography

Intervention Type: PROCEDURE

Echocardiography was performs prior to and within 60 seconds of completing the standard Bruce treadmill protocol.

Interventions

Stress Echocardiography

Echocardiography was performs prior to and within 60 seconds of completing the standard Bruce treadmill protocol.

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• 2 of 5 criteria for metabolic syndrome
• Ability to exercise for 45 min 5 days a week

Exclusion Criteria

• No diabetes
• Established coronary disease

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of Missouri-Columbia

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Tom R Thomas, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Missouri-Columbia

Kevin C Dellsperger, MD, PhD

Role: STUDY_DIRECTOR

University of Missouri-Columbia

Anand Chockalingam, MD

Role: STUDY_DIRECTOR

University of Missouri-Columbia

References

Chockalingam A, Linden MA, Dellsperger KC, Thomas TR. Correlation of Normal Diastolic Cardiac Function With VO in the Metabolic Syndrome. Prev Cardiol. 2009 Summer;12(3):163-8. doi: 10.1111/j.1751-7141.2009.00027.x.

Reference Type: RESULT

PMID: 19523060 (View on PubMed)

Other Identifiers

R01DK067036

Identifier Type: NIH

Identifier Source: secondary_id

View Link

R01DK067036 (Echo substudy)

Identifier Type: -

Identifier Source: org_study_id