Safety and Tolerability QAT370 Compared to Tiotropium in Patients With Chronic Obstructive Pulmonary Disease

NCT ID: NCT00532350

Last Updated: 2020-12-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

22 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-07-31

Study Completion Date

2008-01-31

Brief Summary

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This study will assess the safety and tolerability of QAT370 compared to tiotropium in patients with COPD.

Detailed Description

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Conditions

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Chronic Obstructive Pulmonary Disease

Keywords

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COPD pharmacokinetics plethysmography cycle ergometry exercise testing spirometry

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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1

QAT370

Group Type EXPERIMENTAL

QAT370

Intervention Type DRUG

2

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

3

Tiotropium

Group Type ACTIVE_COMPARATOR

Tiotropium

Intervention Type DRUG

Interventions

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QAT370

Intervention Type DRUG

Placebo

Intervention Type DRUG

Tiotropium

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients between 40 and 80 years of age with controlled COPD.
* Women must be surgically sterilized or postmenopausal. Additional birth control and post-menopausal information will be available at time of enrollment.
* Body mass index (BMI) must be within the range of 18 to 32 kg/m2

Exclusion Criteria

* Participation in any interventional clinical investigation with 4 weeks of study start
* Blood loss or donation of 400 mL or more within 2 months of study start Significant illness (other than respiratory) within 2 weeks of study start
* Past medical personal or close family history of clinically significant ECG abnormalities
* Any medical condition that may interfere with exercise testing or that may make spirometry unsafe
* A known hypersensitivity to the drug.
* History of immunocompromise, including a positive HIV test result.
* History of drug or alcohol abuse within 12 months of study start
* Any condition that may compromise patient safety
Minimum Eligible Age

40 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Novartis

INDUSTRY

Sponsor Role lead

Responsible Party

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Novartis

Principal Investigators

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Novartis

Role: PRINCIPAL_INVESTIGATOR

Investigative site

Locations

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Novartis investigative site

Berlin, , Germany

Site Status

Novartis Investigative site

Mannheim, , Germany

Site Status

Novartis Investigative site

Wiesbaden, , Germany

Site Status

Countries

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Germany

Related Links

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https://www.novctrd.com/ctrdweb/trialresult/trialresults/pdf?trialResultId=2637

Results for CQAT370A2103 can be found on the Novartis Clinical Trial Results Website

Other Identifiers

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CQAT370A2103

Identifier Type: -

Identifier Source: org_study_id