Efficacy and Safety (Including 24-hour Holter Monitoring) of Tiotropium Inhalation Capsules in Patients With COPD

NCT ID: NCT00239460

Last Updated: 2013-11-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

196 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-07-31

Brief Summary

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The objective of this study is to evaluate the effect of inhaled tiotropium bromide on trough FEV1 and to assess the cardiac effects through 12-lead and Holter ECG monitoring in patients with COPD.

Detailed Description

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Conditions

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Pulmonary Disease, Chronic Obstructive

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Interventions

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Tiotropium

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* History of COPD, FEV1 less than or equal to 65%, FEV1/FVC less than or equal 70%
* Smoking history greater than or equal to 10 pack years
* Not history of clinical diagnosis of asthma and/or atopy
* A history of thoracotomy with pulmonary resection
* Patients requiring the use of supplemental oxygen therapy for \>12 hours per day
* Chronic use of systemic corticosteroids in an unstable daily dose
* Patients with a recent history of myocardial infarction
* A known hypersensitivity to anticholinergic drugs
Minimum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Boehringer Ingelheim

INDUSTRY

Sponsor Role lead

Principal Investigators

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Boehringer Ingelheim Study Coordinator

Role: STUDY_CHAIR

Boehringer Ingelheim

Locations

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Attn: William C. Bailey, M.D.

Birmingham, Alabama, United States

Site Status

Boehringer Ingelheim Investigational Site

Phoenix, Arizona, United States

Site Status

Olive View UCLA Medical Center

Sylmar, California, United States

Site Status

Rocky Mountain Center for Clinical Research

Wheat Ridge, Colorado, United States

Site Status

Respiratory Diseases (111A)

Bay Pines, Florida, United States

Site Status

Boehringer Ingelheim Investigational Site

Pembroke Pines, Florida, United States

Site Status

Boehringer Ingelheim Investigational Site

Coeur d'Alene, Idaho, United States

Site Status

LSU Health Sciences Center

Shreveport, Louisiana, United States

Site Status

Pulmonary and Critical Care Services, PC

Albany, New York, United States

Site Status

The Oregon Clinic

Portland, Oregon, United States

Site Status

Boehringer Ingelheim Investigational Site

Charleston, South Carolina, United States

Site Status

Boehringer Ingelheim Investigational Site

Houston, Texas, United States

Site Status

Countries

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United States

References

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Hohlfeld JM, Furtwaengler A, Konen-Bergmann M, Wallenstein G, Walter B, Bateman ED. Cardiac safety of tiotropium in patients with COPD: a combined analysis of Holter-ECG data from four randomised clinical trials. Int J Clin Pract. 2015 Jan;69(1):72-80. doi: 10.1111/ijcp.12596. Epub 2014 Dec 11.

Reference Type DERIVED
PMID: 25496316 (View on PubMed)

Other Identifiers

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205.284

Identifier Type: -

Identifier Source: org_study_id