Analog Classroom Study Comparison of ADDERALL XR With STRATTERA in Children Aged 6-12 With ADHD

NCT ID: NCT00506727

Last Updated: 2021-06-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

215 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-08-05

Study Completion Date

2004-07-02

Brief Summary

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Evaluate the behavioral effects of ADDERALL XR versus STRATTERA under controlled conditions utilizing the SKAMP deportment scale.

Detailed Description

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Conditions

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ADHD

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Study Groups

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Adderall XR

Group Type EXPERIMENTAL

Mixed amphetamine salts (ADDERALL XR)

Intervention Type DRUG

Atomoxetine hydrochloride

Group Type ACTIVE_COMPARATOR

Atomoxetine hydrochloride

Intervention Type DRUG

Interventions

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Mixed amphetamine salts (ADDERALL XR)

Intervention Type DRUG

Atomoxetine hydrochloride

Intervention Type DRUG

Other Intervention Names

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Strattera

Eligibility Criteria

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Inclusion Criteria

* Primary diagnosis of ADHD combined subtype or predominantly hyperactive-impulsive subtype, based on psychiatric evaluation
* Capable of understanding and following classroom instructions
* Generally functioning academically at age-appropriate levels

Exclusion Criteria

* ADHD, predominantly inattentive subtype
* Controlled or uncontrolled comorbid psychiatric diagnosis (except ODD) with significant symptoms such as PTSD, psychosis, bipolar disease, severe OCD, severe depressive or severe anxiety disorder
* Documented history of aggressive behavior serious enough to preclude participation in regular classroom activities
* Documented allergies or intolerance to either of the active treatments or tricyclic antidepressants
Minimum Eligible Age

6 Years

Maximum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Shire

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Study Director

Role: STUDY_DIRECTOR

Takeda

Locations

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Massachusetts General Hospital

Boston, Massachusetts, United States

Site Status

Countries

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United States

References

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Wigal SB, McGough JJ, McCracken JT, Biederman J, Spencer TJ, Posner KL, Wigal TL, Kollins SH, Clark TM, Mays DA, Zhang Y, Tulloch SJ. A laboratory school comparison of mixed amphetamine salts extended release (Adderall XR) and atomoxetine (Strattera) in school-aged children with attention deficit/hyperactivity disorder. J Atten Disord. 2005 Aug;9(1):275-89. doi: 10.1177/1087054705281121.

Reference Type RESULT
PMID: 16371674 (View on PubMed)

Related Links

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Other Identifiers

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SLI381-404

Identifier Type: -

Identifier Source: org_study_id

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