Phase I Study With AZD2171 in Patients With Advanced Solid Malignant Tumors and Liver Metastases

NCT ID: NCT00501605

Last Updated: 2011-01-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-02-28

Study Completion Date

2006-02-28

Brief Summary

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Single centre recruiting approximately 80 patients who are given a rising single, followed by multiple, ascending oral dose of AZD2171, assessing the safety and tolerability of AZD2171 in patients with solid tumors and metastatic liver disease.

Detailed Description

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Conditions

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Advanced Solid Tumor Liver Metastases

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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AZD2171

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Provision of written informed consent
* Male/female, 18 yr or over
* WHO status 0-2
* Refractory advanced solid tumor

Exclusion Criteria

* Radiotherapy within 4 weeks of starting AZD2171 treatment
* Low haemoglobin level
* Low platelet or neutrophil counts
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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AstraZeneca

INDUSTRY

Sponsor Role lead

Principal Investigators

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Nick Botwood, BSc, MBBS, MRCP, MFPM

Role: STUDY_DIRECTOR

AstraZeneca

J. Drevs, PD

Role: PRINCIPAL_INVESTIGATOR

Klinik fur.Internistische Onkologie

Locations

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Research Site

Freiburg im Breisgau, , Germany

Site Status

Countries

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Germany

Other Identifiers

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D8480C00001

Identifier Type: -

Identifier Source: org_study_id

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