A Study of XL844 Administered as a Single Agent and in Combination With Gemcitabine in Adults With Advanced Malignancies

NCT ID: NCT00475917

Last Updated: 2015-08-21

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: PHASE1
• Total Enrollment: 28 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2007-05-31
• Study Completion Date: 2008-12-31

Brief Summary

The purpose of this study is to determine a safe dose of XL844 in combination with gemcitabine, how often it should be taken, and how well people with cancer tolerate the combination of gemcitabine and XL844.

Conditions

Cancer; Lymphoma

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

1

Group Type: EXPERIMENTAL

XL844

Intervention Type: DRUG

Gelatin capsules supplied as 5-mg, 25-mg, and 100-mg strengths; twice-weekly dosing.

Gemcitabine

Intervention Type: DRUG

once-weekly 30-minute IV infusion

Interventions

XL844

Gelatin capsules supplied as 5-mg, 25-mg, and 100-mg strengths; twice-weekly dosing.

Intervention Type: DRUG

Gemcitabine

once-weekly 30-minute IV infusion

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. The subject has a histologically confirmed advanced malignancy (solid tumor or lymphoma) that is metastatic or unresectable, and for which standard curative or palliative measures do not exist or are no longer effective, and there are no therapies known to prolong survival.

2. The subject has disease that is assessable by tumor marker, physical, or radiologic means.

3. The subject is ≥18 years old.

4. The subject has an ECOG (Eastern Cooperative Oncology Group) performance status of ≤2.

5. The subject has adequate organ and marrow function.

6. The subject has the capability of understanding the informed consent document and has signed the informed consent document.

7. Sexually active subjects (male and female) must use medically acceptable methods of contraception during the course of the study.

8. Female subjects of childbearing potential must have a negative pregnancy test at screening.

9. If a subject has received more than three prior regimens of cytotoxic chemotherapy, more than two biologic regimens, or more than 3000 cGy to >25% of his or her bone marrow, the investigator must discuss with the sponsor regarding subject suitability before enrollment.

10. The subject has had no other diagnosis of malignancy (unless non-melanoma skin cancer, in situ carcinoma of the cervix, or a malignancy diagnosed ≥5 years ago, and has had no evidence of disease for 5 years prior to screening for this study).

Exclusion Criteria

1. The subject has received anticancer treatment (eg, chemotherapy, radiotherapy, immunotherapy, biologic therapy, investigational agent, or hormones) within 14 days prior to the first dose of study drug.

2. The subject has not recovered to Grade ≤1 from adverse events (AEs) due to investigational agents or other medications administered more than 30 days prior to the first dose of study drug.

3. The subject has received radiation to >25% of his or her bone marrow within 30 days of XL844 treatment.

4. The subject has a primary brain tumor or known brain metastases.

5. The subject has uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, hypertension, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.

6. The subject is pregnant or breastfeeding.

7. The subject is known to be positive for the human immunodeficiency virus (HIV).

8. The subject is unable or unwilling to abide by the study protocol or cooperate fully with the investigator or designee.

9. The subject has a known allergy or hypersensitivity to any of the components of the XL844 formulation or gemcitabine.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Exelixis

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Memorial Sloan-Kettering Cancer Center

New York, New York, United States

M.D. Anderson Cancer Center

Houston, Texas, United States

Countries

United States

Other Identifiers

XL844-002

Identifier Type: -

Identifier Source: org_study_id