Phase I, Open-label, Dose Escalation of AZD4877 in Hematologic Malignancies

NCT ID: NCT00460460

Last Updated: 2011-01-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE1

Total Enrollment

75 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-03-31

Study Completion Date

2007-08-31

Brief Summary

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The primary purpose of this study is to find out what the maximum tolerated dose is for an experimental drug called AZD4877 based on the side effects experienced by patients that receive AZD4877 on a weekly basis in these diseases.

Detailed Description

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Conditions

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Lymphoma

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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AZD4877

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients with AML, a certain type of ALL, NHL and MM
* certain types of cancer of the lymph nodes
* certain types of leukemias (blood cancers)
* disease has or will fail with other treatments
* relatively good overall health other than your cancer

Exclusion Criteria

* poor bone marrow function (not producing enough blood cells)
* serious heart conditions
* poor liver or kidney function
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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AstraZeneca

INDUSTRY

Sponsor Role lead

Principal Investigators

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Judith Ochs, MD

Role: STUDY_DIRECTOR

AstraZeneca

Locations

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Research site

Buffalo, New York, United States

Site Status

Research Site

New York, New York, United States

Site Status

Research Site

Toronto, Ontario, Canada

Site Status

Countries

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United States Canada

Other Identifiers

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D2782C00002

Identifier Type: -

Identifier Source: org_study_id

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