Cortisol in the Treatment of Phobias

NCT ID: NCT00451750

Last Updated: 2010-01-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-05-31

Study Completion Date

2009-09-30

Brief Summary

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The aim of this prospective, double-blind, placebo-controlled, randomized study is to investigate if glucocorticoid treatment, in combination with exposure therapy, helps to reduce phobic fear in patients with phobia.

Detailed Description

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Conditions

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Phobia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Interventions

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Cortisol

20 mg for 3 times

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

\- Female and male patients with a specific phobia (fear of heights) according to DSM-IV criteria.

Exclusion Criteria

* Severe acute or chronic somatic diseases
* Psychiatric disorder other than specific phobia
* Topic glucocorticoid therapy (for large skin parts)
* Inhaled glucocorticoids
* Psychotropic medication
* Pregnancy
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Basel, Switzerland

OTHER

Sponsor Role collaborator

University of Zurich

OTHER

Sponsor Role lead

Responsible Party

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University of Zurich

Principal Investigators

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Dominique JF de Quervain, MD, Prof.

Role: PRINCIPAL_INVESTIGATOR

University of Zurich

Frank Wilhelm, Prof.

Role: PRINCIPAL_INVESTIGATOR

University of Basel

Locations

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University of Basel

Basel, , Switzerland

Site Status

Countries

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Switzerland

References

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Soravia LM, Heinrichs M, Aerni A, Maroni C, Schelling G, Ehlert U, Roozendaal B, de Quervain DJ. Glucocorticoids reduce phobic fear in humans. Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5585-90. doi: 10.1073/pnas.0509184103. Epub 2006 Mar 27.

Reference Type BACKGROUND
PMID: 16567641 (View on PubMed)

Other Identifiers

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2007DR3069

Identifier Type: -

Identifier Source: org_study_id

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