Project to Investigate Ways to Reduce the Spread of Influenza in Schools and Households With Children

NCT ID: NCT00446628

Last Updated: 2016-01-27

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 3360 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2007-01-31
• Study Completion Date: 2009-09-30

Brief Summary

The purpose of this study is to understand the spread of influenza (flu) in schools and households with elementary (K-5) school children, and develop ways to reduce the flu using non-pharmaceutical means.

Detailed Description

Pandemic influenza threatens to cause substantial disability, death, and societal disruption and to overwhelm health care systems in the United States and around the world. Because effective vaccines may not be available during the initial months of a pandemic, and because anti-viral medication is both largely ineffective and in short supply, non-pharmacological personal protection and behavioral changes may be the only means to combat the epidemic. In our computational modeling work (through the Models of Infectious Disease Agent Study network), we have shown the potential value of multiple targeted and layered non-pharmacological interventions in blunting the peak impact and slowing of a pandemic (Nature, in press).

Phase 1 of the project will be a pilot study in two elementary schools in the City of Pittsburgh. The project has already obtained agreement to collaborate from the Pittsburgh Public School System and we have assembled a multi-disciplinary team of epidemiologists, systems analysts, modelers, community and minority health workers, and virologists to implement the project. Phase one was in 2 schools.

Phase 2 will be similar to Phase 1 with the addition of additional schools and application of a "hygiene" intervention to selected schools and families. Phase 2 is in 10 schools with 3800 students.

Specific aims (year 02):

Primary

1. Measure the effectiveness of non-pharmaceutical interventions (NPIs) in reducing influenza rates among enrolled students in the intervention and control schools when influenza is known to be circulating in the community. [Note: Enrolled, for purposes of PIPP, will indicate students who present with ILI, consent to participate, and are tested for influenza during the flu season.] Secondary: School-Based

2. Measure number of absentees and determine the reason for absence by using a school based absentee illness surveillance system prior to and through the end of influenza season.

3. Measure the effectiveness of NPIs in reducing absenteeism from all causes, including illness/URI, illness/ILI, illness/other, and illness/GI through the end of influenza season.

4. Measure the effectiveness of NPIs in reducing secondary spread of ILI within classrooms of participating schools.

5. Assess adoption of NPI behaviors and activities in classrooms of intervention schools.

Secondary: Home-Based

6. Measure the effectiveness of NPIs in reducing secondary cases of ILI within families of enrolled school children with influenza.

7. Assess adherence of families of enrolled school children with influenza to isolation-related NPI behaviors and activities.

Tertiary

8. Measure correlation between rapid flu testing and PCR testing for influenza.

9. Collect and archive influenza specimens for future molecular epidemiological studies.

10. Contribute a sample of influenza-positive specimens to the CDC for national influenza surveillance purposes.

Conditions

Influenza

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: NONE

Study Groups

intervention

Five elementary school received intervention consistin of training in hand and respiratory hygiene, and access to hand sanitizer

Group Type: EXPERIMENTAL

behaviors reducing spread of influenza

Intervention Type: BEHAVIORAL

Non-pharmaceutical interventions for flu prevention

control

Five elementary school received no training or hand sanitizer.

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

behaviors reducing spread of influenza

Non-pharmaceutical interventions for flu prevention

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Students in grades K-8 with a current influenza-like illness (ILI) during flu season.ILI defined as an oral or aural temperature > 100 °F AND either new onset cough or sore throat.Flu season is defined as December, 2006 through March/April, 2007.
• Parental consent and student assent.

• Shares living space with K-8 child who has current influenza infection.
• Parental consent and child assent in the case of minors.
• Individual consent if over the age of 18.
• Will continue in the study even if student with confirmed influenza withdraws from the study.

Exclusion Criteria

• The participant has a medical or mental health condition which in the judgment of the investigator is a barrier to safe participation.
• The participant is unable to tolerate a swab or capillary finger stick.
• There is a delay in notification or testing such that symptoms have resolved.

• The participant has a medical or mental health condition which in the judgment of the investigator is a barrier to safe participation.
• The participant is younger than 6 months.
• The participant is unable to tolerate a swab or capillary finger stick.

• Minimum Eligible Age: 6 Months
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Kiren Mitruka

FED

Sponsor Role: lead

Responsible Party

Kiren Mitruka

Medical officer

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

Donald S Burke, MD

Role: PRINCIPAL_INVESTIGATOR

University of Pittsburgh

Sam Stebbins, MD, MPH

Role: PRINCIPAL_INVESTIGATOR

University of Pittsburgh School of Public Health

Locations

University of Pittsburgh

Pittsburgh, Pennsylvania, United States

Countries

United States

Other Identifiers

CDC-U01 CI000435-01

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

CDC-NCPDCID-CC-0612047

Identifier Type: -

Identifier Source: org_study_id