ACEIs and ARBs Treatment in Diabetic Patients -Drug Interactions and Adverse Drug Effects

NCT ID: NCT00437775

Last Updated: 2007-02-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-01-31

Study Completion Date

2007-03-31

Brief Summary

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Proteinuria is an expression of diabetic nephropaty in type 1 and type 2 patients. Hypertenshion treatment and decreasing urine protein excretion, slow down renal deterioration. Treating diabetic ,hypertensive patients with Angiotensin Converting Enzyme inhibitors (ACEi), Angiotensin receptor blockers (ARBs)is common practice. The aim of our work is to examine 1.The prevalence of ACE and ARB treatment in diabetic patients with or without hypertension.2. Adverse drug reactions of ACEi and ARBs alone or in combination.

Detailed Description

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The study group- men and women with diabetes mellitus type 2,who were hospitalized in the department of internal medicine in Assaf- Harofeh Medical Center.

During hospitalization, data regarding the clinical history,chronic diseases and drugs were collected from the medical files. Blood tests results were recorded during hospitalization .The patients were asked about adverse drug effects.

Conditions

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Diabetes Mellitus Type 2

Study Design

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Observational Model Type

DEFINED_POPULATION

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Type 2 diabetic patients admitted to department of Internal Medicine in Assaf Harofeh Medical Center

Exclusion Criteria

* Type 1 diabetes mellitus
Minimum Eligible Age

40 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Assaf-Harofeh Medical Center

OTHER_GOV

Sponsor Role lead

Principal Investigators

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Ahuva Golik, Assoc. Prof.

Role: STUDY_DIRECTOR

Sackler School of Medicine, Tel-Aviv University

Alina Alperovich, B.Pharm

Role: PRINCIPAL_INVESTIGATOR

Assaf-Harofeh Medical Center

Lila Akivison, MSc.Pharm

Role: STUDY_CHAIR

Assaf-Harofeh Medical Center

Sofia Berkovitch, MSc. Pharm

Role: STUDY_CHAIR

Assaf-Harofeh Medical Center

Gabby Elbaz, MD

Role: STUDY_CHAIR

Assaf- Hrofech Medical Senter

Locations

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Assaf Harofeh Medical Center

Ẕerifin, , Israel

Site Status RECRUITING

Countries

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Israel

Central Contacts

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Alina Alperovich, B.Pharm

Role: CONTACT

972-547616736

Gabby Elbaz, MD

Role: CONTACT

972-8-977-9240

Facility Contacts

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Alina Alperovich, B.Pharm

Role: primary

972-547616736

References

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Winkelmayer WC, Zhang Z, Shahinfar S, Cooper ME, Avorn J, Brenner BM. Efficacy and safety of angiotensin II receptor blockade in elderly patients with diabetes. Diabetes Care. 2006 Oct;29(10):2210-7. doi: 10.2337/dc06-0570.

Reference Type RESULT
PMID: 17003295 (View on PubMed)

Andros V, Egger A, Dua U. Blood pressure goal attainment according to JNC 7 guidelines and utilization of antihypertensive drug therapy in MCO patients with type 1 or type 2 diabetes. J Manag Care Pharm. 2006 May;12(4):303-9. doi: 10.18553/jmcp.2006.12.4.303.

Reference Type RESULT
PMID: 16792436 (View on PubMed)

Burnier M, Zanchi A. Blockade of the renin-angiotensin-aldosterone system: a key therapeutic strategy to reduce renal and cardiovascular events in patients with diabetes. J Hypertens. 2006 Jan;24(1):11-25. doi: 10.1097/01.hjh.0000191244.91314.9d.

Reference Type RESULT
PMID: 16331093 (View on PubMed)

Other Identifiers

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167/06

Identifier Type: -

Identifier Source: org_study_id

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