Characterization of Macroprolactinemia

NCT ID: NCT00436111

Last Updated: 2007-02-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Study Classification

OBSERVATIONAL

Study Start Date

2005-01-31

Study Completion Date

2006-12-31

Brief Summary

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The purpose of this study is to clarify the nature of macroprolactin which has recently been highlighted because of the high prevalence and a diagnostic pitfall of hyperprolactinemia. The results of this study are beneficial for the patients to whom unnecessary medications and unnecessary radiological examinations have been performed.

We used the remained serum samples taken for routine prolactin determination during the past several years. Since the blood was basically taken to examine the causes of hyperprolactinemia and only remained serum samples were used for this study, the Ethics Committee of Kobe City General Hospital judged that it was not required to obtain approval number.

Detailed Description

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Conditions

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Hyperprolactinemia

Study Design

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Observational Model Type

DEFINED_POPULATION

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Clinical diagnosis of hyperprolactinemia
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Kansai Medical University

OTHER

Sponsor Role lead

Principal Investigators

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Naoki Hattori, M.D., Ph.D.

Role: STUDY_CHAIR

Department of Pharmacology, Kansai Medical University

Locations

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Kansai Medical University

Osaka, Osaka, Japan

Site Status

Countries

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Japan

References

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Hattori N, Nakayama Y, Kitagawa K, Ishihara T, Saiki Y, Inagaki C. Anti-prolactin (PRL) autoantibody-binding sites (epitopes) on PRL molecule in macroprolactinemia. J Endocrinol. 2006 Aug;190(2):287-93. doi: 10.1677/joe.1.06871.

Reference Type RESULT
PMID: 16899562 (View on PubMed)

Hattori N, Ikekubo K, Nakaya Y, Kitagawa K, Inagaki C. Immunoglobulin G subclasses and prolactin (PRL) isoforms in macroprolactinemia due to anti-PRL autoantibodies. J Clin Endocrinol Metab. 2005 May;90(5):3036-44. doi: 10.1210/jc.2004-1600. Epub 2005 Feb 1.

Reference Type RESULT
PMID: 15687336 (View on PubMed)

Hattori N, Inagaki C. Anti-prolactin (PRL) autoantibodies cause asymptomatic hyperprolactinemia: bioassay and clearance studies of PRL-immunoglobulin G complex. J Clin Endocrinol Metab. 1997 Sep;82(9):3107-10. doi: 10.1210/jcem.82.9.4250.

Reference Type RESULT
PMID: 9284753 (View on PubMed)

Hattori N, Ishihara T, Ikekubo K, Moridera K, Hino M, Kurahachi H. Autoantibody to human prolactin in patients with idiopathic hyperprolactinemia. J Clin Endocrinol Metab. 1992 Nov;75(5):1226-9. doi: 10.1210/jcem.75.5.1430082.

Reference Type RESULT
PMID: 1430082 (View on PubMed)

Other Identifiers

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KK-2007-1

Identifier Type: -

Identifier Source: org_study_id

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