Urinary Excretion of Enteroviruses From Children With a Presumed Enteroviral Infection

NCT ID: NCT00426699

Last Updated: 2011-05-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

82 participants

Study Classification

OBSERVATIONAL

Study Start Date

2006-06-30

Study Completion Date

2008-11-30

Brief Summary

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Enteroviruses can infect most human organ systems, especially the heart, nervous system and pancreas. Whether Enteroviruses can also affect the kidneys is not known yet. Therefore we will analyze urine of children with a suspected enteroviral infection for enteroviruses and signs of kidney infection.

Detailed Description

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Enteroviruses have been shown to cause mesangioproliferation and glomerulonephritis in mice (especially coxsackievirus B4). In some cases, large amounts of IgA are deposited in the mesangium, resembling human IgA-nephropathy. In humans, case reports indicate the propensity of certain enteroviruses to cause kidney infections.

Our project aims to analyze urine of children with suspected enteroviral infections (e.g. meningitis, myocarditis, sepsis of the newborn etc.) to identify cases suspicious of concomitant enteroviral kidney affection. To achieve this aim, enterovirus-PCRs will be performed and microhematuria searched for.

Conditions

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Enterovirus Infections

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* children, suspected of suffering from an enteroviral infection
Maximum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Insel Gruppe AG, University Hospital Bern

OTHER

Sponsor Role lead

Responsible Party

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Department of Nephrology and Hypertension, Inselspital, University Hospital Bern

Principal Investigators

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Andreas Pasch, MD

Role: PRINCIPAL_INVESTIGATOR

University of Bern

Locations

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Dept. Nephrology & Hypertension, Univ. Hospital Bern

Bern, Canton of Bern, Switzerland

Site Status

Countries

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Switzerland

Other Identifiers

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BE002

Identifier Type: -

Identifier Source: org_study_id

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