Phase II Study of RR110 in Patients With Active Crohn's Disease

NCT ID: NCT00417391

Last Updated: 2008-05-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-12-31

Study Completion Date

2008-05-31

Brief Summary

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The purpose of this study is to evaluate the safety, efficacy and pharmacokinetics profile of 1 and 4 mg/kg/day RR110 administrated orally for 8 weeks in patients with active Crohn's disease.

Detailed Description

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Conditions

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Crohn's Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1 mg RR110

1 mg RR110

Group Type EXPERIMENTAL

RR110 (Tamibarotene)

Intervention Type DRUG

1 mg RR110

4 mg RR110

4 mg RR110

Group Type EXPERIMENTAL

RR110 (Tamibarotene)

Intervention Type DRUG

4 mg RR110

Interventions

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RR110 (Tamibarotene)

1 mg RR110

Intervention Type DRUG

RR110 (Tamibarotene)

4 mg RR110

Intervention Type DRUG

Other Intervention Names

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Tamibarotene Am80 Tamibarotene Am80

Eligibility Criteria

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Inclusion Criteria

* Patients with CDAI score ranging from 220 to 450
* Patients with CRP \> 1 mg/dL
* Patients who can be hospitalized at least 2 weeks after first administration

Exclusion Criteria

* Patients who have previously used anti-TNF antibody, cyclosporine, methotrexate or tacrolimus within 12 weeks of screening
* Patients who have had surgical bowel resections within 4 weeks of screening
* Patients who have previously used total parental nutrition or more than 900 kcal/day of enteral nutrition within 4 weeks of screening
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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R&R Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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R&R Inc.

Principal Investigators

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Toshifumi Hibi, M.D., Ph.D.

Role: STUDY_CHAIR

Keio University

Locations

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Toyohashi, Aichi-ken, Japan

Site Status

Sakura, Chiba, Japan

Site Status

Sapporo, Hokkaido, Japan

Site Status

Nishinomiya, Hyōgo, Japan

Site Status

Fujisawa, Kanagawa, Japan

Site Status

Nakagami, Okinawa, Japan

Site Status

Ōtsu, Shiga, Japan

Site Status

Shinjuku, Tokyo, Japan

Site Status

Countries

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Japan

Other Identifiers

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1101-01

Identifier Type: -

Identifier Source: org_study_id