Determinants of Corticosteroid Insensitivity in Smokers With Asthma
NCT ID: NCT00411320
Last Updated: 2011-08-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
53 participants
INTERVENTIONAL
2007-01-31
2010-09-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Group 1
Smokers with asthma
oral steroid-dexamethasone
2 week steroid trial
Group 2
Ex-smokers with asthma
oral steroid-dexamethasone
2 week steroid trial
Group 3
Non-smokers with asthma
oral steroid-dexamethasone
2 week steroid trial
Group 4
Non smokers without asthma
No interventions assigned to this group
Group 5
Smokers without asthma or COPD
No interventions assigned to this group
Interventions
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oral steroid-dexamethasone
2 week steroid trial
Eligibility Criteria
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Inclusion Criteria
* Asthma duration of 6 months or greater
* Stable asthma
* Age 18-60
* Treatment with inhaled corticosteroids
* Smoking history consistent with group
* smokers with asthma: \> or = 5 pack years and currently smoking more than 5 cigarettes per day
* ex-smokers: smoking ceased \> or = two years prior to recruitment, minimum 5 pack year history
* non-smokers: no smoking history
Exclusion Criteria
* Treatment with \> 2000 mcg beclomethasone (or equivalent) per day
* Subject requires oral corticosteroids to maintain asthma control
* Subject requires oral theophylline to maintain asthma control
* Recent treatment with oral corticosteroids
* Pregnancy or subject planning to become pregnant
18 Years
60 Years
ALL
No
Sponsors
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Chief Scientist Office of the Scottish Government
OTHER_GOV
University of Glasgow
OTHER
Responsible Party
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NHS Greater Glasgow and Clyde (North Glasgow University Hospitals Division)
Principal Investigators
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Mark Spears, MRCP
Role: PRINCIPAL_INVESTIGATOR
University of Glasgow
Neil C Thomson, FRCP
Role: PRINCIPAL_INVESTIGATOR
University of Glasgow
Rekha Chaudhuri, MD
Role: PRINCIPAL_INVESTIGATOR
University of Glasgow
Locations
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Asthma Research Unit, Glasgow University
Glasgow, Scotland, United Kingdom
Countries
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References
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Spears M, McSharry C, Donnelly I, Jolly L, Brannigan M, Thomson J, Lafferty J, Chaudhuri R, Shepherd M, Cameron E, Thomson NC. Peripheral blood dendritic cell subtypes are significantly elevated in subjects with asthma. Clin Exp Allergy. 2011 May;41(5):665-72. doi: 10.1111/j.1365-2222.2010.03692.x. Epub 2011 Feb 21.
Related Links
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Other Identifiers
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AR002
Identifier Type: -
Identifier Source: org_study_id
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