Efficacy and Safety of Grazax in Children

NCT ID: NCT00408616

Last Updated: 2009-03-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

253 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-11-30

Study Completion Date

2007-11-30

Brief Summary

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The purpose of this study is to investigate if immunotherapy with Grazax is safe and reduces the hayfever symptoms and the use of symptom relieving medications in children during the grass pollen season

Detailed Description

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Conditions

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Allergy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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1

Grazax treatment

Group Type EXPERIMENTAL

Grazax-R

Intervention Type BIOLOGICAL

Grass tablet, 75.000 SQ per day for one year

2

Grazax Placebo

Group Type PLACEBO_COMPARATOR

Grazax Placebo

Intervention Type BIOLOGICAL

Grazax Placebo, 0 SQ tablet per day for one year

Interventions

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Grazax-R

Grass tablet, 75.000 SQ per day for one year

Intervention Type BIOLOGICAL

Grazax Placebo

Grazax Placebo, 0 SQ tablet per day for one year

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Boys and girls 5-16 years of age
* A clinical history of grass pollen induced hayfever
* Positive Skin Prick Test to Phleum pratense
* Positive specific IgE against Phleum pratense

Exclusion Criteria

* History of seasonal hayfever symptoms (and/or asthma) caused by another allergen than Phleum pratense during or overlapping the grass pollen season
* History of perennial hayfever (and/or asthma) that needs medication due to an allergen to which the child is regularly exposed
* History of severe asthma
* Current severe atopic dermatitis
Minimum Eligible Age

5 Years

Maximum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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ALK-Abelló A/S

INDUSTRY

Sponsor Role lead

Principal Investigators

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Friedrich Kaiser, Dr. med.

Role: PRINCIPAL_INVESTIGATOR

Tangstedter Landstrasse 77, 22415 Hamburg, Germany

Locations

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Tangstedter Landstrasse 77

Hamburg, , Germany

Site Status

Countries

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Germany

References

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Bufe A, Eberle P, Franke-Beckmann E, Funck J, Kimmig M, Klimek L, Knecht R, Stephan V, Tholstrup B, Weisshaar C, Kaiser F. Safety and efficacy in children of an SQ-standardized grass allergen tablet for sublingual immunotherapy. J Allergy Clin Immunol. 2009 Jan;123(1):167-173.e7. doi: 10.1016/j.jaci.2008.10.044.

Reference Type RESULT
PMID: 19130937 (View on PubMed)

Other Identifiers

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GT-12

Identifier Type: -

Identifier Source: org_study_id

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