Neural Correlates of Lower Extremity Motor Recovery in Stroke Patients: Longitudinal Diffusion Spectrum Imaging Studies

NCT ID: NCT00407628

Last Updated: 2013-07-08

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 24 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2006-08-31
• Study Completion Date: 2009-07-31

Brief Summary

To investigate the relationship between the integrity of the white matter, including the corticospinal tracts and the corpus callosum, with the recovery of lower extremity function in patients with cerebral stroke at the subacute and chronic stages.

Detailed Description

Recent studies have provided strong evidence that motor recovery after adult ischemic stroke is a function of neural plasticity. Up to date, it remains largely unknown as to the relationship between the integrity of the subcortical white matter with the lower extremity function recovery. Given the fact that the white matter is more resistant to ischemia after acute stroke than the gray matter (Falcao et al., 2004) and that the intensity of white matter in stroke has been found to be much greater in many brain areas in stroke than in healthy controls (Wen et al., 2004), it is of interest to study how the integrity of the subcortical white matter, primarily the corticospinal tracts and the corpus callosum, contributes to the recovery of lower extremity function in subacute and chronic stroke with lesions involving different areas of the brain.

Conditions

Stroke

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: RETROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• between 30 to 80 years old
• diagnosis of the first-time onset of stroke as confirmed by imaging studies
• within 30 days post onset University Hospital
• brain lesions mainly involving either the cortical primary motor cortex (M1) area or confined to the subcortical (M1 spared)
• No neurological or orthopedic problems which would affect their lower extremity function
• no contraindications for MRI studies

Exclusion Criteria

• medically unstable
• unable to communicate with the experimenters

• Minimum Eligible Age: 30 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

National Science and Technology Council, Taiwan

OTHER_GOV

Sponsor Role: collaborator

National Taiwan University Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Pei-Fang Tang, PhD

Role: STUDY_CHAIR

National Taiwan University Hospital

Locations

School and Graduate Institute of Physical Therapy College of Medicine, National Taiwan University

Taipei, Taiwan, China

Countries

China

Other Identifiers

NSC95-2314-B-002-238-MY3

Identifier Type: -

Identifier Source: secondary_id

9561703031

Identifier Type: -

Identifier Source: org_study_id