SAPPHIRE Worldwide: Stenting and Angioplasty With Protection in Patients At High-Risk for Endarterectomy

NCT ID: NCT00403078

Last Updated: 2020-08-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

21008 participants

Study Classification

OBSERVATIONAL

Study Start Date

2006-10-31

Study Completion Date

2014-11-30

Brief Summary

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The primary objective of this study is to assess the outcomes of stenting with distal protection in the treatment of obstructive carotid artery disease. The devices to be utilized are the Cordis PRECISE® Nitinol Stent Systems (5.5F and 6F) and the Cordis ANGIOGUARD™ XP Emboli Capture Guidewire (ECGW).

Detailed Description

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Carotid Artery Stenting

Conditions

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Carotid Artery Disease

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* High-surgical risk patients to be treated consistent with IFU labeling
* The patient or legally authorized representative has signed a written informed consent and HIPAA authorization, prior to the procedure, using a form that is approved by the Institutional Review Board or Medical Ethics Committee.

Exclusion Criteria

* Patients not treated per the IFU
* Patients who are contraindicated per the IFU
* Patients previously enrolled in the study
* Patients requiring stenting of in-stent restenosis after CAS
* Inability or refusal to provide informed consent.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Cordis Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Rajesh Dave, MD

Role: PRINCIPAL_INVESTIGATOR

Harrisburg Hospital, 2808 Old Post Rd., Harrisburg, PA 17110

Robert Hibbard, MD

Role: PRINCIPAL_INVESTIGATOR

Bryan LGH Heart Institute, 1500 South 48th St, Suite 400, Lincoln, NE 68506

Douglas Massop, MD

Role: PRINCIPAL_INVESTIGATOR

Iowa Clinic-Heart and Vascular Care, 5950 University Ave, West Des Moines, IA 50266

Christopher Metzger, MD

Role: PRINCIPAL_INVESTIGATOR

The Heart Center, PC, 2050 Meadowview Parkway, Kingsport, TN 37660

Locations

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Christiana Care Health Services

Newark, Delaware, United States

Site Status

Iowa Clinic, Heart & Vascular Care

West Des Moines, Iowa, United States

Site Status

Bryan LGH Heart Institute

Lincoln, Nebraska, United States

Site Status

Harrisburg Hospital

Harrisburg, Pennsylvania, United States

Site Status

The Heart Center, PC

Kingsport, Tennessee, United States

Site Status

Countries

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United States

References

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Massop D, Dave R, Metzger C, Bachinsky W, Solis M, Shah R, Schultz G, Schreiber T, Ashchi M, Hibbard R; SAPPHIRE Worldwide Investigators. Stenting and angioplasty with protection in patients at high-risk for endarterectomy: SAPPHIRE Worldwide Registry first 2,001 patients. Catheter Cardiovasc Interv. 2009 Feb 1;73(2):129-36. doi: 10.1002/ccd.21844.

Reference Type RESULT
PMID: 18924164 (View on PubMed)

Other Identifiers

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P06-3603

Identifier Type: -

Identifier Source: org_study_id

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