The Effect of Methylphenidate on Motor Learning in Stroke Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE4

Total Enrollment

13 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-11-30

Study Completion Date

2008-03-31

Brief Summary

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The purpose of the study is to determine whether methylphenidate facilitates so called short-term plasticity as measures with transcranial magnetic stimulation, in patients with stroke.

Detailed Description

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Stroke patients are to be examined with transcranial magnetic stimulation (TMS) before and after a short training session. TMS will be used to demonstrate changes in cortical excitability (motor threshold) and intracortical inhibition and facilitation. The effect of methylphenidate on baseline TMS measures will be evaluated as well as the effect on training induced changes in TMS measures (by comparing baseline and posttraining measures). The patients will be trained on two separate occasions, to compare the effect of Methylphenidate to placebo.

Conditions

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Cerebrovascular Accident

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Interventions

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Methylphenidate

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Less than two months after first stroke.
* Moderate to light hand paralysis
* Measurable MEP in the abductor pollicis brevis muscle
* Able to read and understand the written information
* Signed informed consent

Exclusion Criteria

* Epilepsy
* Glaucoma
* Hyperthyroidism
* Cardiac arrythmia
* Known heart disease or angina.
* Metal implants
* Pacemaker
* Pregnancy
* Diastolic BP\>100 mmHg
* In treatment with MAO-inhibitor, SSRIs og Ritalin

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Principal Investigators

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Jakob U Blicher, MD

Role: PRINCIPAL_INVESTIGATOR

Hammel neurocenter Aarhus University Hospital Denmark

Locations

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Department of neurology

Aarhus, Aarhus, Denmark

Site Status

Hammel neurocenter

Hammel, Hammel, Denmark

Site Status

Countries

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Denmark

Other Identifiers

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2006-002554-29

Identifier Type: -

Identifier Source: org_study_id