A Phase I/II Study of MGCD0103 (MG-0103) in Combination With Gemcitabine

NCT ID: NCT00372437

Last Updated: 2015-07-01

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1/PHASE2
• Total Enrollment: 47 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2006-09-30
• Study Completion Date: 2008-12-31

Brief Summary

Inthis study, MGCD0103, a new anticancer drug under investigation, is given three times weekly in combination with gemcitabine to patients with solid tumours.

Conditions

Tumors

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

1

Group Type: EXPERIMENTAL

MGCD0103

Intervention Type: DRUG

MGCD0103 as an oral dose three times per week.

Gemcitabine

Intervention Type: DRUG

Gemcitabine 1000mg/m\<2\> intravenously days 1, 8, 15 of a 28 day cycle.

Interventions

MGCD0103

MGCD0103 as an oral dose three times per week.

Intervention Type: DRUG

Gemcitabine

Gemcitabine 1000mg/m\<2\> intravenously days 1, 8, 15 of a 28 day cycle.

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Patients must have histologically or cytologically documented cancer: Phase I--solid tumors where gemcitabine is considered standard of care; refractory solid tumor with no reasonable likelihood of achieving clinical benefit with existing therapies, that has failed to respond to standard therapy, has progressed despite standard therapy, or for which no standard therapy exists. Phase II--locally advanced and measurable (non-resectable III) or metastatic (Stage IV) pancreatic cancer.
• Patients with known CNS metastases may be enrolled on Phase I or II only if they meet the following criteria:

• They have received radiotherapy for their CNS disease;
• They have had steroids discontinued for at least 1 month prior to study entry;
• They have had a CT or MRI of the brain within 1 month of study entry that shows stable disease; and d)they are free of neurological symptoms.
• Karnofsky performance status of 70 or greater.
• Age 18 years and over.
• Laboratory requirements (must be done within 14 days prior to study initiation):

• Hematology: White Blood Cells (WBC)≥3 x 10<9>/L (≥ 3000/mm3);
• Absolute Neutrophil Count (ANC) ≥1.5 x 10<9>/L (≥1500/mm3);
• Platelets ≥100 x 10<9>/L (≥100,000/mm3);
• Chemistry: Total Bilirubin ≤1.5 x Upper Limit of Normal(ULN);
• AST(SGOT)and ALT(SGPT)≤3 x ULN; ≤ 5 x ULN if documented liver metastases;
• Serum Creatinine ≤1.5 x ULN or calculated creatinine clearance ≥50 mL/min;
• Urinalysis: Proteinuria <1 mg/dl or 500 mg protein/24 hours if dipstick ≥2+.
• Patients or their legal representative must be able to read (or have read to them), understand, and sign a written informed consent (approved by the institutional review board/Ethics Committee (IRB/EC)) within 14 days prior to start of treatment.

Exclusion Criteria

• Patients with another active cancer (excluding basal cell carcinoma or cervical intraepithelial neoplasia (CIN/cervical in situ or melanoma in situ). (Phase II portion only)
• Pregnant or lactating women. Women of child bearing potential (WOCBP) must have a negative serum pregnancy test documented within 7 days prior to starting study drug.
• WOCBP and men whose partners are WOCBP must use an acceptable method of contraception while enrolled on this study, and for a period of 3 months following study drug treatment. Patients unwilling or unable to follow this guideline will be excluded. Investigators should follow their Institutional standard regarding acceptable methods of contraception.
• Patients with uncontrolled concomitant illness, active infection requiring i.v. antibiotics, or uncontrolled infections, or a fever >38.5C on the day of scheduled dosing.
• Patients with serious illnesses, medical conditions, or other medical history, including laboratory results, which, in the investigator's opinion, would be likely to interfere with a patient's participation in the study, or with the interpretation of the results.
• Patients who have been treated with any investigational drug within 28 days prior to study initiation (an investigational drug is one for which there is no approved indication), or who are receiving concurrent treatment with other experimental drugs or anti-cancer therapy.
• Known hypersensitivity to HDAC inhibitors or to any of the components of MG-0103.
• Known hypersensitivity to gemcitabine.
• Prior treatment with gemcitabine (during the expanded phase II portion only).
• Known HIV or known active Hepatitis B or C.
• Any condition (e.g., known or suspected poor compliance, psychological instability, geographical location, etc.) that, in the judgment of the investigator, may affect the patient's ability to sign the informed consent and undergo study procedures.
• Any condition that will put the patient at undue risk or discomfort as a result of adherence to study procedures. For example, consider requirement to take MG-0103 with a low pH drink and recommendation to avoid agents that increase gastric pH.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Mirati Therapeutics Inc.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Gregory Reid, MSc, MBA

Role: STUDY_DIRECTOR

MethylGene Inc.

Locations

Indiana University Cancer Center

Indianapolis, Indiana, United States

Veterans Affairs Medical Center

Kansas City, Kansas, United States

Duke University Medical Center

Durham, North Carolina, United States

Gabrail Cancer Center

Canton, Ohio, United States

Pennsylvania Presbyterian Medical Center

Philadelphia, Pennsylvania, United States

Vanderbilt University Medical Center

Nashville, Tennessee, United States

McGill University/Dept Oncology

Montreal, Quebec, Canada

CHUS Hopital Fleurimont

Sherbrooke, Quebec, Canada

Countries

United States; Canada

Other Identifiers

0103-006

Identifier Type: -

Identifier Source: org_study_id